The prophylactic effect of IL-17A DNA vaccine on arthritis

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10470
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Osaka University
• Principal Investigator: tomita tetsuya 大阪大学, 医学系研究科, 寄附講座准教授 (30283766)
• Co-Investigator(Kenkyū-buntansha): 中神 啓徳 大阪大学, 医学系研究科, 寄附講座教授 (20325369) ; 二井 数馬 大阪大学, 医学系研究科, 助教 (30588380) ; 吉川 秀樹 大阪大学, 医学系研究科, 理事・副学長 (60191558) ; 郡山 弘 大阪大学, 医学系研究科, 助教 (60710093)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 整形外科学 / リウマチ病学 / DNAワクチン / IL-17A

Outline of Final Research Achievements

We examined the prophylactic effect of IL-17 A DNA vaccine on two different arthritis mouse models. Production of anti-IL-17A antibody was confirmed after IL-17 A DNA vaccination. The arthritis score and destruction of joints was significantly suppressed　by IL-17 A DNA vaccination in both arthritis models. These results demonstrated the prophylactic effect of IL-17 A DNA vaccine on joint destruction in arthritis.

Free Research Field

整形外科学