2017 Fiscal Year Final Research Report
A study for the mechanism of postoperative congnitive dysfunction and development of prevention method
| Project/Area Number |
15K10533
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology
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| Research Institution | Gunma University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
MIWA Hideki 群馬大学, 医学系研究科, 助教 (80468488)
HAYASHI Kunihiko 群馬大学, 保健学研究科, 教授 (80282408)
TAKATSURU Yusuke 群馬大学, 医学系研究科, 助教 (30446265)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | ミクログリア / サイトカイン / ミノサイクリン |
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| Outline of Final Research Achievements |
Postoperative model animals were prepared using SAMP 8 which is a senescence promoting mouse and control mouse SAMPR 1 and examined whether antibiotic minocycline has a preventive effect on postoperative cognitive dysfunction (POCD). We discovered that POCD is caused by surgical invasion rather than anesthesia, that minocycline has a preventive effect on POCD. In SAMP 8, the minocycline suppressed the increase in TNF-α concentration on the first day after surgery. It was suggested that minocycline reduces the cytokine concentration in the blood and exerts the preventive effect of POCD.
The MINPOC-J trial, which examines the effect of minocycline on postoperative cognitive function, nearly completed acquisition of the scheduled number of data.
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| Free Research Field |
麻酔科学
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