2017 Fiscal Year Final Research Report
Analysis of circulating cancer stem cells in endometrial cancer
| Project/Area Number |
15K10708
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
藤原 浩 金沢大学, 医学系, 教授 (30252456)
尾崎 聡 金沢大学, 大学病院, その他 (40401921)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | Endometrial cancer / Cancer stem cells / p53 / ERβ |
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| Outline of Final Research Achievements |
We examined the immunohistochemical expression profiles of p53 and estrogen receptor (ER) β proteins in patients with endometrial endometrioid carcinoma who underwent surgical treatment at our hospital (n = 154). By multivariate analysis, we found that histological grades, detection of immunoreactive p53 and high expression of ERβ (high-ERβ) were independently associated with metastasis and/or recurrence. Among these parameters, the sensitivity and negative predictive values of high-ERβ were very high (up to 100%). The disease- free survival of patients who were double-positive for p53-stained and high-ERβ was significantly shorter than that in other patients. These results suggess that double-positivity for p53-stained and high-ERβ may provide a promising clinical indicator to predict the risk of progression in endomterial cancer. Furthermore, p53 and ERβ expression may be associated with cancer stem cells (CSCs), especially CD133 and CD117 CSC markers.
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| Free Research Field |
婦人科腫瘍学
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