2018 Fiscal Year Final Research Report
The mechanism of Inner ear dysfunction in ANCA-associated vasculitis
| Project/Area Number |
15K10759
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Jichi Medical University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2019-03-31
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| Keywords | 中耳炎 / 抗好中球細胞質抗体 |
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| Outline of Final Research Achievements |
ANCA(Antineutrophil cytoplasmic antibody) associated vasculitis is defined as a minor arterial vasculitis caused by the ANCA. Most of the intractable otitis media had not been explained by the known etiology may be this ANCA associated vasculits(OMAAV). This research, aimed to clarify the mechanism of inner ear damage of OMAAV by using the model mice. Propylthiouracil (PTU)is an antithyroid drug for the treatment of hyperthyroidism, and about 30% of the patients received PTU produce MPO positive ANCA associated vasculitis(AAV). The histological findings of MPO-ANCA positive AAV model mice induced by PTU did not show the remarkable vasculitis in the inner ear.
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| Free Research Field |
耳鼻咽喉科学
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| Academic Significance and Societal Importance of the Research Achievements |
ANCA関連血管炎性中耳炎の聴力障害には、蝸牛神経、血管条、中耳の血管炎に伴う血流障害、肉芽増生、炎症が原因となっていると考えられる。作成を試みたANCA関連血管炎モデルマウスでは形態学、生化学的には、内耳に有意な変化は見られなかった。一方で多くのバイオマーカ-の発現が観察された。マウスの種類によりANCA発現の変化もあること、ANCA関連血管炎が全身疾患でありながら症状の好発する部位、臓器に差があること、なかでも耳症状が初発しやすいことから、外耳、中耳および蝸牛神経周囲血管における血管炎、好中球細胞外トラップ（NETｓ）の発現のさらなる検討が必要である。
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