Development of novel therapeutic strategies in head and neck squamous cell carcinoma based on microRNA-mediated cancer pathways

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10801
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Chiba University
• Principal Investigator: SEKI NAOHIKO 千葉大学, 大学院医学研究院, 准教授 (50345013)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: マイクロRNA / 頭頸部扁平上皮癌 / 癌抑制遺伝子 / インテグリン / 発現プロファイル

Outline of Final Research Achievements

In this study, we construct the microRNA (miRNA) expression signature of head and neck squamous cell carcinoma (HNSCC). Our signature revealed that a total of 160 miRNAs (44 upregulated and 116 downregulated) were aberrantly expressed in cancer tissues. Expression of miR-150-5p (guide strand miRNA) and miR-150-3p (passenger strand miRNA) were significantly silenced in cancer tissues. Ectopic expression of mature miRNAs, miR-150-5p and miR-150-3p inhibited cancer cell aggressiveness. We identified that integrin α3 (ITGA3) and integrin α6 (ITGA6) were coordinately regulated by these miRNAs in HNSCC cells.

Free Research Field

ゲノム医学