2018 Fiscal Year Final Research Report
Feasibility study of fluorescence-guided surgery using 5-aminolevulinic acid in head and neck cancer.
Project/Area Number |
15K10824
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Otorhinolaryngology
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Research Institution | Kitasato University |
Principal Investigator |
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Research Collaborator |
Yamashita Taku
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Project Period (FY) |
2015-04-01 – 2019-03-31
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Keywords | 頭頸部癌 / 蛍光ナビゲーション手術 / 5-アミノレブリン酸 |
Outline of Final Research Achievements |
Fluorescence imaging using 5-aminolevulinic acid (ALA) was performed in one case with hypopharyngeal cancer and 2 cases with tongue cancer with ultrasensitive digital camera mounted tailor-made LED light source, though, the imaging did not detect significant signal. Because tumor differentiation presumably affected the unfavorable results, the case with poor differentiated squamous cell carcinoma (SCC) came to prospective objective. However, there was no candidate meeting conditions. Thus, the fluorescence imaging using ALA might be unpractical at least in the case with differentiated SCC which fills majority of head and neck cancer.
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Free Research Field |
耳鼻咽喉科・頭頸部外科
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Academic Significance and Societal Importance of the Research Achievements |
上記の結果から、低分化型扁平上皮癌症例における蛍光検出可否は依然として不明であり、また光源や検出機器の改良により結果が変わる可能性がある。しかし、少なくとも現状において頭頸部癌の多くを占める中~高分化型扁平上皮癌症例では、ALAによる蛍光ナビゲーション手術は実用的でない可能性が示された。
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