2017 Fiscal Year Final Research Report
Practicability of end-to-side neurorrhaphy as Schwann cell provider to acellular nerve graft
| Project/Area Number |
15K10949
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Plastic surgery
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
水野 博司 順天堂大学, 医学部, 教授 (80343606)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 神経再生 / 端側神経縫合 / 人工神経 / 無細胞化神経 / 神経移植 / シュワン細胞 / 脂肪組織由来幹細胞 |
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| Outline of Final Research Achievements |
To improve usefulness of artificial nerve graft, we have proceeded the research to use end-to-side neurorrhaphy as Schwann cell provider to acellular nerve graft.
In this research, we compared the effect of end-to-side neurorrhaphy to the acellular nerve graft to injecting Adipose-derived stem cells(ASCs). Both procedures improved functional recovery after the graft. However, the difference between two procedures were not obvious and there was no synergic effect even combining them simultaneously. We try to conduct further research to find even more effective use of end-to-side neurorrhaphy as Schwann cell provider to acellular nerve graft in the future.
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| Free Research Field |
再建外科
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