Examination of the physiological role of Runx2 in the regulation of phosphorus levels through the regulation of Galnt3 expression

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K11016
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Morphological basic dentistry
• Research Institution: Nagasaki University
• Principal Investigator: ROKUTANDA Satoshi 長崎大学, 医歯薬学総合研究科(歯学系), 客員研究員 (60549608)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: Runx2 / Galnt3 / phosphorus / FGF23

Outline of Final Research Achievements

The serum levels of phosphorus are regulated by FGF23. FGF23, which is mainly produced in bone, inhibits reabsorption of phosphorus in kidney, and inhibits absorption of calcium and phosphorus in intestine by inhibiting the production of active vitamin D. Galnt3（UDP-N-acetyl-D-galactosamine:polypeptide N-acetyl-D-galactosaminyltransferase 3）inhibits the processing of FGF23 by mucin type O-glycosylation of FGF23, and maintains the activity of FGF23. Runx2 induced Galnt3 expression in osteoblasts and chondrocytes. Runx2 was involved partly in the regulation of the serum levels of phosphorus through the regulation of Galnt3 expression.

Free Research Field

口腔外科学