Fundamental research toward development of infection prevention against oral cavity-derived multidrug resistant Staphylococcus aureus

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K11017
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Morphological basic dentistry
• Research Institution: Kagoshima University
• Principal Investigator: KAWADA-MATSUO Miki 鹿児島大学, 医歯学域歯学系, 准教授 (20527048)
• Co-Investigator(Kenkyū-buntansha): 大貝 悠一 鹿児島大学, 医歯学域歯学系, 助教 (40511259) ; 小松澤 均 鹿児島大学, 医歯学域歯学系, 教授 (90253088)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: MRSA / 口腔定着阻害 / 抗菌物質 / 薬剤耐性

Outline of Final Research Achievements

The aim of this study is to develop a method for inhibiting oral colonization of Staphylococcus aureus (Sa) . We set up 2 researches both colonization mechanism and searching antibacterial factor toward development of multidrug resistant Staphylococcus aureus (MRSA) in oral cavity.　We revealed that glycyrrhetic acid (GRA) and succinic acid (GR - SU) exerted antibacterial activity againist clinical isolated MRSA. We discovered the novel drug resistance mechanism of MRSA by exposing sub-MIC concentration on nisin, a bacteriocin derived from lactic acid bacteria.
From these experiments, we discovered a novel naturally occurring antimicrobial substance effective for MRSA and a novel drug resistance mechanism of MRSA against antibacterial substances of bacteria, and it will be important to conduct fundamental research on inhibition of MRSA colonization in oral cavity in the future.

Free Research Field

口腔細菌学分野