Inibition of lymphangiogenesis in oral squamous cell carcinoma

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K11097
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: Hyogo Medical University
• Principal Investigator: YAMANEGI KOJI 兵庫医科大学, 医学部, 講師 (00434944)
• Co-Investigator(Kenkyū-buntansha): 中正 恵二 兵庫医科大学, 医学部, 教授 (00217712) ; 山田 直子 兵庫医科大学, 医学部, 講師 (10319858) ; 西浦 弘志 兵庫医科大学, 医学部, 助教 (90284760) ; 野口 一馬 兵庫医科大学, 医学部, 准教授 (50309473) ; 小越 菜保子 大阪医科大学, 医学部, 助教 (60509115)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 新生リンパ管抑制 / 扁平上皮癌 / 血管新生抑制因子

Outline of Final Research Achievements

We investigated the anti-angiogenic and/or endogenous anti-angiogenic factors inhibited lymphangiogenesis on oral squamous cell carcinoma cells (OSCC). Real time Microarray PCR revealed that some candidate of anti-angiogenic and/or endogenous anti-angiogenic factors were found out OSCC treated epigenetic modulators, such histone deacetylase inhibitor, DNA methylation inhibitor and mTOR inhibitor. To narrow down them further, these candidate factors were performed immunoprecipitation with VEGF-C or VEGFR-3. The candidate factor inhibits growth of lymphendothelial cells and tube formation. This result suggest that cancer-induced lymphangiogenesis could be controlled by epigenetic modulator.

Free Research Field

口腔病理学