2017 Fiscal Year Final Research Report
Establishment of order-made periodontal regenerative therapy based on micro RNA profile
| Project/Area Number |
15K11215
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
水野 智仁 広島大学, 病院(歯), 講師 (60325181)
兼田 英里 広島大学, 病院(歯), 歯科診療医 (30736426)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 歯周組織再生療法 / 間葉系幹細胞 / micro RNA / 転写因子 / 再生歯学 |
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| Outline of Final Research Achievements |
Some micro RNAs expressed characteristically in periodontal cells and mesenchymal stem cells (MSC) were identified and regulatory factors of micro RNA expression were also suggested.
From these results, in periodontal regenerative therapy with cell transplantation, selection of optimal regulatory factors based on each micro RNA profile of donor MSC can lead to enhancement of periodontal differentiation in transplantation site, finally, effective order made periodontal regenerative therapy can be established.
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| Free Research Field |
歯周病学
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