Development of novel therapeutic methods for malignant tumors targeting PDE2 gene mutation

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K11241
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Mie University
• Principal Investigator: MURATA TAKU 三重大学, 医学部附属病院, 講師 (80242965)
• Co-Investigator(Kenkyū-buntansha): 清水 香澄 三重大学, 医学部附属病院, 助教 (20378368)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: phosphodiesterase / cAMP / melanoma

Outline of Final Research Achievements

Phosphodiesterase (PDE) is a degrading enzyme of intracellular transmitter (cAMP and/or cGMP) and 11 types (PDE 1 - PDE 11) are present. We have reported that PDE 2 is involved in the invasion of malignant tumor cells, and the mutation of a specific site of PDE2 gene. Therefore, we investigated the relationship between cell invasion and this mutation. Invasion was promoted by overexpression of mutant in oral malignant melanoma cells without expression of PDE2. And, invasion cells were heterozygous. From this results, we confirmed that the mutation of PDE 2 may be related to cell invasion.

Free Research Field

口腔外科