Challenge of leptin as new healing accelerant for wound healing and intractable stomatitis

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K11253
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: The University of Tokushima
• Principal Investigator: KUDOH Keiko 徳島大学, 大学院医歯薬学研究部(歯学系), 助教 (70380029)
• Co-Investigator(Kenkyū-buntansha): 宮本 洋二 徳島大学, 大学院医歯薬学研究部(歯学系), 教授 (20200214) ; 工藤 隆治 徳島大学, 大学院医歯薬学研究部(歯学系), 助教 (10263865) ; 玉谷 哲也 徳島大学, 病院, 講師 (30274236) ; 藤澤 健司 徳島大学, 病院, 講師 (40228979) ; 高丸 菜都美 徳島大学, 病院, 助教 (40513031)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: レプチン / 創傷治癒

Outline of Final Research Achievements

This research was carried out to examine the healing promotion effects such as wound healing with the leptin or the extraction socket. As a result, (1) leptin was detected in fibroblasts of mouse skin wound healing, (2) leptin promoted mouse fibroblasts, and (3) skin wound healing and healing of extraction tooth socket delayed slightness in comparison with a wild type with the leptin-deficient (ob/ob) mouse. Leptin was able to suggest possibility with wound healing and a healing of extraction tooth socket promotion effect, but wound healing and healing of extraction tooth socket promotion were not significantly accepted in the experiment that added leptin in ob/ob mouse.

Free Research Field

口腔外科