2017 Fiscal Year Final Research Report
Establishment of surgical treatment of medication-related osteonecrosis of the jaws using tetracycline fluorescent labeling method
| Project/Area Number |
15K11321
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
吉賀 大午 九州歯科大学, 歯学部, 助教 (10507784)
松尾 拡 九州歯科大学, 歯学部, 教授 (70238971)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | MRONJ / ARONJ / BRONJ / ミノマイシン / 骨蛍光標識法 |
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| Outline of Final Research Achievements |
Objectives: The purpose of this study was to determine the potential of tissue fluorescence imaging byusing Visually Enhanced Lesion Scope (VELscope_) for the detection of osteonecrosis of Medication related Osteonecrosis of the Jaw.MRONJ mdel rat could be made by bone drilling with LPS. MRONJ model rats ware divided into two groups; Minomycine administrated group (subcutaneous injection of Minomycin for 7 days) :M(+) andMinomycin non-sdministrated group : M(-). Bone fluorescence evaluation by VEL scope was compared between two groups. We got the impression that the contrast between the fluorescent part and the non-fluorescent part was more clear in M(+) group yhan in M(-) group. Histopathological findings of the fluorescent part was normal structure of bone, on the other hand the non-fluorescent part showed necrosis of bone pathological bone.
Conclusion: VELscope examination is a suitable tool to visualize necrotic areas of the bone in MRONJ.
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| Free Research Field |
口腔外科
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