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2016 Fiscal Year Final Research Report

Dietary factors and aging control: Glycosylation modified diets

Research Project

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Project/Area Number 15K12340
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Eating habits
Research InstitutionThe University of Tokushima

Principal Investigator

MIYAMOTO Kenichi  徳島大学, 大学院医歯薬学研究部(医学系), 教授 (70174208)

Project Period (FY) 2015-04-01 – 2017-03-31
Keywordsリン / 寿命 / 腎臓 / 食事 / klotho
Outline of Final Research Achievements

Dietary modifications such as calorie restrictions have a lifespan extension effect. Klotho deficient (KL) mice are short-lived, aged-promoted model mice. The inorganic phosphate (Pi) -restricted diet prolongs the life span of KL mice and restores its phenotype. In this study, we investigated whether Pi-restricted diet causes the modification of the N-glycosylation of Npt2c. By Pi-restricted diet, Npt2c and Klotho were induced, and the N-glycosylation pattern of Npt 2c was changed. KLNpt2c (Klotho/Npt2c DKO) mice showed the rescued KL phenotypes. In conclusion, Pi restriction was considered to be a diet inducing N-glycan modification

Free Research Field

生活科学・食生活学

URL: 

Published: 2018-03-22  

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