Experimental study on preventive effect of whole body vibration on metastatic progression of breast cancer to bone

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K12509
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: The University of Tokushima
• Principal Investigator: Matsumoto Takeshi 徳島大学, 大学院社会産業理工学研究部(理工学域), 教授 (30249560)
• Co-Investigator(Kenkyū-buntansha): 福島 修一郎 大阪大学, 基礎工学研究科, 助教 (40362644)
• Co-Investigator(Renkei-kenkyūsha): FUKUSHIMA Takashi 筑波大学, 医学医療系, 准教授 (30323299) ; UESUGI Kentaro 高輝度光科学研究センター, 放射光研究所, 副主幹研究員 (80344399)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: がん骨転移 / 微振動刺激 / 骨メカノセラピー

Outline of Final Research Achievements

Whole body vibration (WBV) is reported to be bone-anabolic; however, its preventive effect on metastatic progression of breast cancer to bone remains unclear. In the present study, bone destruction by breast cancer metastasis was examined in tumor-bearing mice exposed to WBV. Breast cancer cells 4T1 was implanted at the mammary fat pad of female BALB/c mice aged 8 wk. One day after the implantation, mice were divided into three groups (n=10 each): W_45, W_90, and s_W, exposed to 45-Hz, 0.3g-WBV, 90Hz, 0.3g-WBV, and sham-WBV, respectively, for 20 min/day, 5 d/wk for 3 wk. The reduction of both cortical and cancellous bone volumes was suppressed in W_90. The serum osteocalcin level in W_90 mice was elevated compared with that in s_W. These results indicated that WBV may mitigate or retard the metastatic progression of breast cancer in a frequency-dependent manner, likely owing to the WBV-enhanced osteogenic activity.

Free Research Field

生体医工学