2016 Fiscal Year Final Research Report
Thermodynamics for Single/Multicellular Transition
| Project/Area Number |
15K13617
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Physical chemistry
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| Research Institution | Saitama University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Keywords | 単細胞多細胞転移 / 細胞性粘菌 / NADH蛍光 |
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| Outline of Final Research Achievements |
A plausible reason of an evolution of a multicellular organism from single cellular one was studied experimentally by using starvation induced aggregation of Dictyostelium. While the total number of Dictyostelium cells were constant, WST measurement showed decrease in total NADH by the aggregation. The amount of NADH in a single cell was detected by fluorescence microscopy. A collision of two free moving cells decreased the fluorescence intensity. After separation, the intensity was recovered. These two types of measurements were harmonized well to indicate that the multicellular organism requested less energy dissipation than that of single cellular system, which means the biological transition of single to multicellular organism was achieved by the thermodynamically.
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| Free Research Field |
物理化学
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