Availability of lactoferrin as a drug delivery system for antidepressant

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K14878
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Integrative animal science
• Research Institution: Tottori University
• Principal Investigator: Takeuchi Takashi 鳥取大学, 農学部, 教授 (20216849)
• Co-Investigator(Renkei-kenkyūsha): TAKEUCHI Takashi 鳥取大学, 農学部, 教授 (10325061)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 行動学 / 鬱 / ストレス / ラクトフェリン

Outline of Final Research Achievements

We investigated an antidepressant like effect of bovine latoferrin (bLf) in repeated forced-swim (FS) stress mice model. Supplemented bLf (1 %) suppressed an immobility time in the FS test. This antidepressant like effect of bLf was disappeared by pre-treatment with a nitric oxide synthase inhibitor or kappa-opioid receptor antagonist. BLf had no effect on the immobility time by combination with fluoxetine, imipramine and pramipexole. While the dopamine D2 receptor mRNA expression in the frontal lobe was significantly increased in the FS treated mice, bLf maintained it as a control level. We couldn’t detect transported bLf nor liposomal bLf in the hippocampus following even after the iv injection.

Free Research Field

獣医臨床検査学