2016 Fiscal Year Final Research Report
Determination of helper T cell fate by amino acid metabolism
| Project/Area Number |
15K15155
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | Ehime University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KUWAHARA Makoto 愛媛大学, 大学院医学系研究科, 助教 (00568214)
SUZUKI Junpei 愛媛大学, 大学院医学系研究科, 助教(特定教員)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | グルタミン代謝 / ヘルパーT細胞 / エピゲノム / サイトカイン |
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| Outline of Final Research Achievements |
After receiving antigenic stimulation, the reprogram of metabolic pathway is induced in CD4 T cells and supports rapid clonal expansion. However, the role of metabolic reprograming in the differentiation of helper T cell (Th) subset remains to be elucidated. In this study, we focused on the role of glutamine metabolism in activated CD4 T cells. We found that glutamine metabolism controls chromatin status at the cytokine gene loci and regulates Th differentiation in part via supplementation of apha-ketoglutarate.
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| Free Research Field |
免疫学
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