2016 Fiscal Year Final Research Report
Study on prostaglandin transporter as a novel target for anti-inflammatory drugs
| Project/Area Number |
15K15181
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Applied pharmacology
|
|---|
| Research Institution | Kanazawa University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
川井 恵一 金沢大学, 保健学系, 教授 (30204663)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
Nakamichi Noritaka 金沢大学, 薬学系, 准教授 (10401895)
|
|---|
| Research Collaborator |
Nakamura Yoshinobu 金沢大学, 大学院
|
|---|
| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Keywords | トランスポーター / プロスタグランジン / 炎症 / 発熱 / 抗炎症薬 / マクロファージ |
|---|
| Outline of Final Research Achievements |
The present study indicates that an important chemical mediator prostaglandin (PG) E2 is transported into acidic organelles including lysosome via OATP2A1, which is a transporter with high affinity to PGE2, in macrophages activated under inflammatory condition, and then it is secreted by exocytosis. Since genetic and chemical suppression of Oatp2a1 attenuated endotoxin-induced fever in rodent models, OATP2A1 is expected to be a novel target for antipyretic drugs.
|
| Free Research Field |
生物薬剤学
|
