2016 Fiscal Year Final Research Report
Development of a novel carrier for tumor associated macrophage and its application to cancer immunotherapy
| Project/Area Number |
15K15185
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied pharmacology
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | ドラッグデリバリーシステム |
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| Outline of Final Research Achievements |
We have been constructed the albumin DDS platform that is albe to create albumin dervaties with active targeting potency and multiple functions. The purpose of the present study is to attempt a developement of novel immunotherapy which convert M2 type tumor associated macrophage to its M1 type. To achive this strategy, it must be nessesary to construct a novel DDS system to TAM. Here, we originally develop a TAM tardeting carrier based on recombinant mannosylated albumin with PEGlation (PEGlated Man-HSA). Actually, this carrier preferentially distributed to tumor tissues and simultaneously reduced the distribution to liver. Using albumin fusion technology, M1-inducers were attached to PEGlated Man-HSA, and it retained M1 inducing ability. Administration of M1-PEGlated Man-HSA caused the alternation of TAM phenotype from M2 type to M1 like type, and hence, suppresed the tumor growth significantly. Thus, M1-PEGlated Man-HSA has a potential as a novel immunotherapy against cancer.
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| Free Research Field |
薬剤学
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