2016 Fiscal Year Final Research Report
Immunological effect of mineral oil
| Project/Area Number |
15K15238
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hygiene and public health
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 鉱物油 / 自己抗体 / マウス / T細胞 |
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| Outline of Final Research Achievements |
I examined the immunological influence of mineral oil by using mouse. We injected pristine, squalene and laxative (mixture of the mineral oil) to mouse peritoneal cavity. And I evaluated the effect to T cell, Macrophage cell and B cell of mineral oil. We extracted single cells from peritoneal cavity and spleen. We separated the extracted cells to T cells, Macrophage cells and B cells. We evaluated T cell surface receptors (CD28, ICOS, CD40L, PD1). Expression of all surface receptors were increased. Macrophage cell has ICOS-L, CD40, PD-L1, PD-L2 surface receptors. The expressions of all surface receptors were decreased. On the other hand, we evaluated the effect to B cell. B cell has ICOS-L, CD40, PD-L1 surface receptors too. The expression of all surface receptors were also decreased. Pristane, squalene and laxative were same effect to T cell, Macrophage cell and B cell. From these results, mineral oil could stimulate T cell but suppress Macrophage cell and B cell.
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| Free Research Field |
公衆衛生
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