Apply for induced pluripotent stem cells in forensic practice

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K15262
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Legal medicine
• Research Institution: Nagasaki University
• Principal Investigator: NAKAHARA Aya 長崎大学, 医歯薬学総合研究科(医学系), 客員研究員 (80719005)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 多能性幹細胞 / 法医剖検症例 / レノックス・ガストー症候群

Outline of Final Research Achievements

In forensic practice, it is very difficult to diagnose the cause of death such as fatal arrhythmia and metabolic disease. induced pluripotent stem (iPS) cells from fibloblast can differentiate cardiomyo-cell and hepatocyte. This means that forensic pathologist easily diagnose functional disease to check electrogram of cardiocyte and evaluate hepatocyte function. In this study, we made iPS cells from an case of Lennox-Gastaut syndrome. Actually, we collected skin tissue and cultured fibroblast from it. After culturing, iPS cells were developed. In future, we will check pluripotent of the cells and will differentiate cardiomyo-cell and hepatocyte.

Free Research Field

法医病理学