Discoery of mechanism for peritoneal metastasis of gastric cancer: targeting cross talk between cancer cell and omentum

2018 Fiscal Year Final Research Report

• Project/Area Number: 15K15295
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Gastroenterology
• Research Institution: Nagoya City University
• Principal Investigator: Shimura Takaya 名古屋市立大学, 大学院医学研究科, 講師 (90405192)
• Project Period (FY): 2015-04-01 – 2019-03-31
• Keywords: 胃癌 / 腹膜転移 / 脂肪 / 大網 / 血管新生

Outline of Final Research Achievements

Conditioned media (CM) derived from OmAd (OmAd-CM) significantly promoted proliferation and migration of GC cells compared to control media. OmAd-CM also reinforced the ability of GC cells inducing EC recruitment and tube formation. The cytokine array identified that protein-X was abundantly contained in OmAd-CM and "Y" is the most expressed among X family. Silencing "Y" from OmAd (siRNA-OmAd) inhibited OmAd-induced cell growth and migration in both GC cell lines, as well as angiogenesis. This phenomenon was validated with xenograft study and human pathological study.

Free Research Field

消化器癌

Academic Significance and Societal Importance of the Research Achievements

胃癌は進行すると高頻度に腹膜転移をきたすが、そのメカニズムは全く不明であることから治療法も限定される。また腹膜転移はCTなどの画像所見にも映らず、診断も困難を極める。
本研究結果により、胃癌が高頻度に腹膜転移をきたす一因を解明できたことにより、今後の新たな治療標的や腹膜転移の診断法の開発につながることが期待される。