2016 Fiscal Year Final Research Report
Pathophysiological analysis using iPS cells from patient with Renal Coloboma syndrome
| Project/Area Number |
15K15328
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Kidney internal medicine
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | ＰＡＸ2 / 腎コロボーマ症候群 |
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| Outline of Final Research Achievements |
In this study, we established disease-specific iPS cells from renal coloboma syndrome with PAX2 gene mutation, which is a rare genetic disorder. To clarify the pathogenesis of this syndrome, we used these iPS cells. The cells were also used to investigate therapeutic target genes.
We induced kidney lineage cells, such as mesoderm and renal tubules, from disease-specific and control iPS cells. In addition, time-sequential expression gene analysis was performed. Some gene expressions were enhanced in response to gene expression of PAX2, and some candidate genes in which expression was reduced in disease specific iPS cells was detected.
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| Free Research Field |
腎臓病
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