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2016 Fiscal Year Final Research Report

Development of biomarker related to gender dysphoria (gender identity disorder) based on whole exome sequencing analysis.

Research Project

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Project/Area Number 15K15433
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Psychiatric science
Research InstitutionSaitama Medical University

Principal Investigator

NAKACHI Yutaka  埼玉医科大学, 医学部, 助教 (10522097)

Co-Investigator(Renkei-kenkyūsha) KOH Jun  大阪医科大学, 医学部, 准教授 (40257853)
OKAZAKI Yasushi  埼玉医科大学, 医学部, 教授 (80280733)
Project Period (FY) 2015-04-01 – 2017-03-31
Keywords性同一性障害 / 性別違和 / 全エクソーム解析 / 全ゲノム解析 / 変異・多型
Outline of Final Research Achievements

This research project was a research plan based on whole-exome analysis of the Gender Identity Disorder/Gender Dysphoria (GID) genome DNA. However, several polymorphisms other than the exon region, which are implied to be related to gender identity disorder, have been reported from foreign research groups. Since it is not possible to detect variants and polymorphisms only up to the flanking range of about 100 bp of the exon region with the original plan, it is necessary to change the method to the whole-genome sequencing analysis and re-analyze our samples. Detection of repetitive sequence polymorphisms found in intron regions and intergenic regions by preliminary analysis was also feasible enough for whole-genome analysis, therefore total genome analysis was performed on ten GID samples by changing the method.

Free Research Field

分子生物学、ゲノム科学、バイオインフォマティクス

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Published: 2018-03-22  

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