Challenge to analyze the regulatory mechanism of bone metabolism by dioxin receptor AhR

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K15757
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Orthodontics/Pediatric dentistry
• Research Institution: The University of Tokushima
• Principal Investigator: IZAWA Takashi 徳島大学, 大学院医歯薬学研究部(歯学系), 助教 (30380017)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 歯学 / 歯科矯正学 / 骨代謝学 / 免疫学

Outline of Final Research Achievements

The mechanism underlying the regulation of AhR expression in osteoclasts and the signaling pathway through which AhR controls osteoclastogenesis remain unclear. We found that the expression of AhR in bone marrow-derived osteoclasts was upregulated by RANKL at an earlier stage. Osteoclast differentiation mediated by the AhR signaling pathway was also regulated in a RANKL/c-Fos-dependent manner. AhR controls osteoclast differentiation via c-Fos/NFATc1 and mitochondrial biogenesis through PGC-1β.

Free Research Field

歯学