MSC exosome-polysaccharide nanogel hybrid for bone regeneration

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K16332
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Kyoto University
• Principal Investigator: Shimoda Asako 京都大学, 工学研究科, 特定研究員 (90712042)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: エクソソーム / マトリックスベシクル / 間葉系幹細胞 / 骨再生 / 糖鎖

Outline of Final Research Achievements

Mesenchymal stem cells (MSCs) can differentiate into various cells and have the potential of therapeutic agents. Exosomes are nano-sized vesicles released from cells and play an important role in cellular communication. Recent studies showed that exosomes from MSCs are considered as a substitution of cell-based therapy. In this study, we collected exosomes from MSCs or osteogenic MSCs and compared their functions. In addition, exosome-like vesicles known as matrix vesicles, released by osteoblasts to induce mineralization, were isolated from osteogenic MSCs. We found the different biological functions between exosomes and matrix vesicles, and glycan profiles of exosomes reflect the biogenesis and cell differentiation.

Free Research Field

バイオマテリアル