2017 Fiscal Year Final Research Report
An experimental study for the effects of fluoride on memory and learning ability of mice by the exposure from during stage from fetus and development
| Project/Area Number |
15K16567
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Basic / Social brain science
|
|---|
| Research Institution | Juntendo University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | フッ素 / 記憶学習能力 / 行動試験 / ＩＱ / Ｂａｒｎｅｓ ｍａｚｅ / Ｙ-maze / 神経毒性 |
|---|
| Outline of Final Research Achievements |
Endemic fluorosis has been reported in many countries. Neurotoxic effects of fluoride on the ability of learning and memory have been focused lately. In this study, we evaluated the neurotoxic effects of fluoride on the learning ability of mice at low doses in the drinking water. Pregnant ICR mice were administered fluoride in the drinking water 0, 5, 25 or 50 ppm. After weaning, the female and male F1 mice were also administered fluoride in the drinking water 0, 5, 25 or 50 ppm until 6-months of age. The mean number of entries without repetition in the 5, 25 or 50 ppm group was significantly level than that in the control at the Y-maze test. The mean time spent in the escape box in the 5, 25 or 50 ppm group was significantly lower than that in the control at the Barnes maze. From the results of the Y-maze test and the Barnes maze, it was demonstrated that the exposure to fluoride drinking during stage from fetus and development induced cognitive deficit.
|
| Free Research Field |
衛生学
|
