2016 Fiscal Year Final Research Report
Roles of endocannabinoid-dependent plasticity in anti-epileptic effects
| Project/Area Number |
15K18331
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 海馬歯状回 / 苔状細胞 / 内因性カンナビノイド / シナプス可塑性 / LTP |
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| Outline of Final Research Achievements |
In the dentate gyrus of hippocampus, excitatory mossy cells and granule cells make reciprocal connections. It is known that these circuits are important for anti-epileptic effects through CB1 receptor activation. It is expected that CB1 receptor-dependent form of synaptic plasticity may contribute to this effect. However, precise mechanisms are still unclear. Here, we examined whether mossy cell-granule cell synapses shows any kinds of long-term synaptic plasticity. By using electrophysiological and optogenetic methods, we found that this synapse exhibited both LTD and LTP. We further found that this LTP requires presynaptic cAMP/PKA signaling. How these long-term synaptic plasticities contribute to anti-epileptic effects will be investigated in the future study.
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| Free Research Field |
神経生理学
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