Functional analysis of Noxo1/Nox1 complex in gastritis and inflammation-associated gastric tumor development

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K18405
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Tumor biology
• Research Institution: Kanazawa University
• Principal Investigator: Echizen Kanae 金沢大学, がん進展制御研究所, 博士研究員 (20743834)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 胃炎 / 胃がん / Nox1

Outline of Final Research Achievements

H.pyroli infection-associated gastritis is one of the main causes of stomach cancer. However, molecular mechanism of gastritis formation is still unrevealed.In previous studies, our group reported that bone marrow-derived cells (BMDCs)-derived TNF-α promotes gastric tumor development. In this study, we investigated the molecular and genetic functions of Noxo1, which is a target of TNF-α, in gastritis and its associated tumorigenesis by using gastric cancer cells, gastritis model mice (C2mE mice) and sporadic gastric tumor model mice (Gan mice). Administration of a Nox inhibitor suppressed proliferation of gastric cancer cells in vitro and further inhibited metaplasia/hyperplasia formation in C2mE mice. We also found that this inhibitor also suppressed proliferation of stem-like cells in the neck region of stomach glands. Accordingly, Noxo1 and the Nox1 complex are possible effective preventive or therapeutic targets for gastritis and gastric cancer.

Free Research Field

腫瘍遺伝学