Roles of TGF-beta in HTLV-1-infected T cells

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K19020
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pathological medical chemistry
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Nagano Yoshiko 東京医科歯科大学, 大学院医歯学総合研究科, 助教 (10723819)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: HTLV-1 / ATL / TGF-beta / IL-10

Outline of Final Research Achievements

Adult T cell Leukemia (ATL) is caused by infection with Human T cell Leukemia Virus-1 (HTLV-1). HTLV-1-specific immune responses are suppressed in ATL, and infected cells themselves are reported to be regulatory T cell-like. In this study, we investigated the regulation of HTLV-1-infected cells by immune suppressive cytokines, TGF-beta and IL-10. We found that the infected cell lines tested responded to TGF-beta weakly whereas IL-10 may promote proliferation of HTLV-1-infected cells.

Free Research Field

腫瘍生物学