Intraductal papillary neoplasm of the bile duct: histological and molecular analysis of 27 patients

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K19064
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Human pathology
• Research Institution: Kurume University
• Principal Investigator: Naito Yoshiki 久留米大学, 大学病院, 講師 (50465712)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 人体病理 / 肝胆道系腫瘍 / 胆管内乳頭状腫瘍 / 分子病理

Outline of Final Research Achievements

In this study, we investigated clinicopathological features, somatic mutation and aberrant expressions in 27 tumors of IPNBs. Macroscopically, there were no cystic types in the extra-IPNB (P<0.001). Immunohistochemically, MUC5AC was expressed in 9 tumors (90%, 9/10) in the intra-IPNB, but was expressed only in 7 tumors in extra-IPNB (41%, 7/17) (P<0.05). There were no differences in the somatic mutation (KRAS and PIK3CA) and aberrant expressions (P53 and P16) There were no significant differences in overall survival between intra-IPNB and extra-IPNB (P=0.899).
This study revealed that intra-IPNB and extra-IPNB present mostly the common clinicopathologic features and molecular analysis.

Free Research Field

人体病理