2017 Fiscal Year Final Research Report
Elucidation of the pathophysiological mechanism of the cases who have no effect on ADHD medication using fNIRS
| Project/Area Number |
15K19627
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Pediatrics
|
|---|
| Research Institution | Jichi Medical University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | 機能的近赤外線分光法 / 注意欠如・多動障害 / 自閉症スペクトラム / 塩酸メチルフェニデート徐放剤 / 抑制機能課題 |
|---|
| Outline of Final Research Achievements |
We examined the neural substrate of the effects of methylphenidate (MPH) on inhibition control in medication-naive ADHD and ADHD with ASD children using fNIRS in a randomized, double-blind, placebo-controlled, crossover design. We investigated cortical activation in the right inferior or middle frontal gyrus (IFG/MFG). In the ADHD without ASD group, unmedicated children exhibited no activation in right IFG/MFG, but MPH medication led to increased right IFG/MFG activation. In the ADHD with ASD group, right IFG/MFG activation was observed before taking MPH, but MPH medication resulted in decreased right IFG/MFG activation. Behavioral assessment showed a significant improvement in both groups one month after oral administration of MPH. In cases where MPH was effective, these results suggest that ADHD with ASD is not simply a mixture of ADHD and ASD pure disorders, but rather that it has its own distinct neuropathology. We will examine cases in which MPH is ineffective as a next step.
|
| Free Research Field |
発達神経学
|
