2017 Fiscal Year Final Research Report
Elucidation of the involvement of extravasated platelets aggregation in graft function after liver transplantation
| Project/Area Number |
15K19844
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General surgery
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 肝移植 / 血小板減少 / 虚血再灌流障害 / 小腸障害 / Milrinone / 血栓性微小血管障害 / ADAMTS13 / von Willebrand factor |
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| Outline of Final Research Achievements |
There is increasing evidence that continuous thrombocytopenia soon after liver transplant (LT) is associated with a less favorable prognosis. Few pathophysiological studies have assessed post-LT thrombocytopenia. We elucidated the pathogenesis of thrombocytopenia after LT using the allograft tissue obtained after transplant and rat hepatic ischemic reperfusion injury model. Platelets were found mainly as extravasated platelet aggregates in local microenvironments. Platelet count after surgery and graft function were lower in EPA positive group than these of negative group. Pre-treatment of phosphodiesterase-3 inhibitor, milrinone by intraportal administration using splenic injection reduced hepatic ischemia-reperfusion injury minimizing small intestinal injury and platelet depletion in rats
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| Free Research Field |
肝移植
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