2016 Fiscal Year Final Research Report
Splemectomy for renal cell carcinoma to restore immuno activity
| Project/Area Number |
15K20076
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Urology
|
|---|
| Research Institution | Kanazawa University |
|---|
Principal Investigator |
|
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| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Keywords | 腎細胞癌 / ケモカイン |
|---|
| Outline of Final Research Achievements |
Tumor-associated macrophages activated cytokine signaling through the interaction with renal cell cancer cells, and then this signaling activated tumor-associated macrophages themselves resulting in myeloid derived suppressor cells. The number of regulatory T cells in blood of advanced kidney caner patients is relatively high and the number of myeloid derived suppressor cells might increase in blood of advanced kidney caner patients,too. As molecular targeting agents can suppress the effect of myeloid derived suppressor cells, it may be better to use IL-2 prior to molecular targeting agents.
|
| Free Research Field |
泌尿器腫瘍学
|
