2017 Fiscal Year Final Research Report
Analysis of interaction between spermatogonial stem cell and Sertoli cell against male infertility
| Project/Area Number |
15K20103
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Urology
|
|---|
| Research Institution | Nagoya City University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | 精子幹細胞 / 男性不妊症 / 停留精巣 |
|---|
| Outline of Final Research Achievements |
Male infertility is one of the most serious problem in our contry. We previously reported that spermatogonial stem cell (SSC) activity indicated future male fertility. However testicular histopathology and molecular mechanism against poor spermatogenesis were not elucidated. In this study, we performed human testicular biopsy and examined SSC funtion and Sertoli cells against risk disease of congenital male infertility. Our study showed that SSC's activity in cryptorchid testes which induced male infertility was already harmed in infant term. Moreover, in adult testes with past history of cryptorchidism might harm testicular function by SSCs activity loss, activation of apoptosis and disturbance of maturation of Sertoli cells.
|
| Free Research Field |
泌尿器科
|
