2016 Fiscal Year Final Research Report
Epithelial to mesenchymal transition thorough GEP100-Arf6-AMAP1 pathway in urothelial cancer
Project/Area Number |
15K20111
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Urology
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Research Institution | Keio University |
Principal Investigator |
Daimon Tatsuaki 慶應義塾大学, 医学部(信濃町), 助教 (40573275)
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Project Period (FY) |
2015-04-01 – 2017-03-31
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Keywords | 上皮間葉転換 / 尿路上皮癌 |
Outline of Final Research Achievements |
We examined EPB4.1L5 expression in urothelial cancer cells, T24 and UMUC-3 by western blotting and immunofluorescence staining. We found the EPB4.1L5 expressin in those cell lines. Retrospective analysis of the clinical records of 165 patients with UTUC (Ta-4N0M0) subjected to radical nephroureterectomy and immunohistochemical examination of EPB4.1L5 expression in those tissues. The score of EPB4.1L5 significantly correlated with tumor grade, pathological T stage, and lymphovascular invasion. The 5-year Kaplan-Meier recurrence-free survival and cancer-specific survival rates were 54.1% and 59.5% in patients with high EPB4.1L5 expression, compared with 81.6% and 87.2%,(all p<0.001) in their counterparts. Multivariate analyses revealed that high expression of EPB4.1L5 was one of the independent prognostic factors for tumor recurrence and cancer specific survival.
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Free Research Field |
泌尿器科学
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