• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2016 Fiscal Year Final Research Report

Characterization of the molecular properties of streptolysin S homolog secreted from Anginosus group streptococci

Research Project

  • PDF
Project/Area Number 15K20361
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Morphological basic dentistry
Research InstitutionThe University of Tokushima

Principal Investigator

Tabata Atsushi  徳島大学, 大学院生物資源産業学研究部, 講師 (10432767)

Project Period (FY) 2015-04-01 – 2017-03-31
KeywordsストレプトリジンS / 口腔連鎖球菌 / アンギノーサス群連鎖球菌 / 病原因子 / Streptococcus
Outline of Final Research Achievements

This study was conducted to reveal the detailed cytotoxic mechanism caused by the action of streptolysin S (SLS) homolog, a peptide hemolysin secreted from Streptococcus anginosus subsp. anginosus (SAA) normally habitual in the human oral cavity. As first, an in vitro preparation system for the recombinant SLS homolog was investigated to prepare the assay tool for the investigation of the cytotoxicity specifically induced by SLS homolog. In addition, the exhaustive gene expression analysis of the human cell line co-cultured with SLS homolog secreting β-hemolytic SAA was conducted and showed some interesting variation of the gene expression profile induced by the action of SLS homolog. From this study, we get on base of the elucidation about the cytotoxic mechanism of SLS homolog secreted from β-hemolytic SAA strain.

Free Research Field

連鎖球菌由来病原因子の機能および細胞応答反応の解析

URL: 

Published: 2018-03-22  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi