2016 Fiscal Year Final Research Report
Periodontal pathogenic infection of risk factor of myocardial hypertrophy
| Project/Area Number |
15K20616
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Periodontology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
Yoshida Asuka 東京医科歯科大学, 歯学部附属病院, 医員 (30749487)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 歯周病 |
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| Outline of Final Research Achievements |
Recently, it's reported that periodontitis is possibility of risk factor of cardiovascular diseases. We revealed that pressure overload induced cardiac hypertrophy, intercellular fibrosis and perivascular fibrosis are accelerated by infection of periodontal pathogen. The purpose of this study was to reveal how to affect infection of periodontal pathogen to cardiac hypertrophy. It's revealed that infection of the other periodontal pathogen deteriorate cardiac hypertrophy and through the protein receptor there was on the cell surface, intercellular fibrosis and expression of inflammation marker were suppressed
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| Free Research Field |
歯周病学分野
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