Development of niucleic delivery system for targeting primary and metametastatic tumor

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K20831
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Physical pharmacy; Biomedical engineering/Biomaterial science and engineering
• Research Institution: Hokkaido University
• Principal Investigator: SATO Yusuke 北海道大学, 薬学研究院, 助教 (10735624)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 脂質ナノ粒子 / 核酸送達 / 粒子径 / がん浸透性 / 動態制御

Outline of Final Research Achievements

Limitation of diffusion of lipid nanoparticles (LNP) in tumor tissues is a severe problem for development of tumor-targeted short interfering RNA (siRNA) delivery system. In this research, to solve the problem, I developed a technology for controlling LNP size and elucidated the cause for a reduced efficiency of siRNA delivery, which is accompanied by downsizing of the siRNA-loaded LNPs.

Free Research Field

薬物送達学