心臓分子イメージング国際共同研究による心不全個別化医療戦略の構築

2019 Fiscal Year Annual Research Report

• Project/Area Number: 15K21774
• Principal Investigator: 樋口 隆弘 岡山大学, 大学院医歯薬学総合研究科, 教授
• Project Period (FY): 2016 – 2019
• Keywords: 分子イメージング / PET / 心不全 / 交感神経 / アンジオテンシン / 細胞治療

Outline of Annual Research Achievements

研究主任者は主な研究拠点をドイツから日本に移した後、日本における分子イメージング研究拠点を立ち上げ、これまでに世界の第一線で研究して得た様々な知見や技術を日本の研究者に指導・譲渡しながら、細胞実験や薬剤合成・標識を進め、海外と同じレベルの研究ができるように環境を整備した。また、国内外との共同研究の強化と継続のため、綿密な研究連携も行なった。特に岡山大学大学院の教授に着任してからは、海外との技術交流・研究者交流を更に加速させ、新たな国内研究拠点の構築と更なる国際共同研究の強化も開始した。
本研究事業にて雇用した事務員、研究員らも研究を補佐・実施して成長し、成果を上げている。京都大学ウイルス・再生医科学研究所、埼玉医科大学、東京大学、金沢大学、京都薬科大学等の国内の他分野に跨る研究グループとの共同研究も順調に進み、その成果は複数の論文、学会で発表している。また、多国間の国際共同研究ネットワークの整備に関しては、ビュルツブルグ大学及びジョンズ・ホプキンス大学との共同研究を既にスタートさせ、また新しくアウグスブルグ大学と共同研究を開始するための準備(国際ミーティングの開催、動物倫理審査の申請、実験環境整備など)も行った。
具体的な研究内容としては、本研究事業で開発した新規交感神経トレーサの有機合成・標識技術を用いて、予備実験としての細胞取り込み、阻害及び刺激実験により、トレーサ取り込みの特異性、取り込まれた後の細胞内動態の評価について、in vitroからin vivoまで、細胞種および動物種を変えながら網羅的研究を行った。また、アンギオテンシン受容体をターゲットとしたトレーサの有機合成、標識実験も行い、特に有効性が高いと見られるトレーサを選別し、性能比較を行うための蛋白結合実験、細胞実験を継続して発展させてきた。これらの研究成果についても、既に複数の論文化に向けて準備中である。

Research Products

• [Int'l Joint Research] Wuerzburg University/Augsburg University(ドイツ)
  • Country Name: GERMANY
  • Counterpart Institution: Wuerzburg University/Augsburg University
• [Int'l Joint Research] Johns Hopkins University(アメリカ)
  • Country Name: アメリカ
  • Counterpart Institution: Johns Hopkins University
• [Journal Article] 68Ga-PSMA I&T PET/CT for primary staging of prostate cancer. (2020)
  • Author(s): Wojciech Cytawa, Anna Katharina Seitz, Stefan Kircher, Kazuhito Fukushima, Johannes Tran-Gia, Andreas Schirbel, Tomasz Bandurski, Piotr Lass, Markus Krebs, Wojciech Polom, Marcin Matuszewski, Hans-Jürgen Wester, Andreas K Buck, Hubert Kübler, Constantin Lapa
  • Journal Title: Eur J Nucl Med Mol Imaging. Volume: 47 Issue: 1 Pages: 168-177
  • DOI: 10.1007/s00259-019-04524-z
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Serial examination of cardiac function and perfusion in growing rats using SPECT/CT for small animals. (2020)
  • Author(s): Tomo Hiromasa, Junichi Taki, Hiroshi Wakabayashi, Anri Inaki, Koichi Okuda, Takayuki Shibutani, Kazuhiro Shiba & Seigo Kinuya
  • Journal Title: Sci Rep. Volume: 10 Issue: 1 Pages: 160
  • DOI: 10.1038/s41598-019-57032-3
  • Peer Reviewed / Open Access
• [Journal Article] Risk stratification based on J-ACCESS risk models with myocardial perfusion imaging. (2020)
  • Author(s): Kenichi Nakajima, Satoko Nakamura, Hiroki Hase, Yasuchika Takeishi, Shigeyuki Nishimura, Yuhei Kawano, Tsunehiko Nishimura
  • Journal Title: J Nucl Cardiol. Volume: 27 Issue: 1 Pages: 41-50
  • DOI: 10.1007/s12350-018-1330-8
  • Peer Reviewed / Open Access
• [Journal Article] Patient Based Bull's Eye Map Display of Coronary Artery and Ventricles From Coronary Computed Tomography Angiography. (2020)
  • Author(s): Fukushima Kenji, Matsuo Yuka, Nagao Michinobu, Sakai Akiko, Kihara Nobuyuki, Onishi Koji, Sakai Shuji
  • Journal Title: J Comput Assist Tomogr. Volume: 44 Issue: 1 Pages: 26-31
  • DOI: 10.1097/RCT.0000000000000966
  • Peer Reviewed / Open Access
• [Journal Article] Comparison of Chemical Exchange Saturation Transfer Imaging with Diffusion-weighted Imaging and Magnetic Resonance Spectroscopy in a Rat Model of Hypoxic-ischemic Encephalopathy. (2020)
  • Author(s): Akiko Ohki, Shigeyoshi Saito, Eri Hirayama, Yusuke Takahashi, Yuko Ogawa, Masahiro Tsuji, Takahiro Higuchi, Kazuki Fukuchi
  • Journal Title: Magn Reson Med Sci.
  • DOI: 10.2463/mrms.mp.2019-0128
  • Peer Reviewed / Open Access
• [Journal Article] Mouse skeletal muscle creatine chemical exchange saturation transfer (CrCEST) imaging at 11.7T MRI. (2020)
  • Author(s): Takahashi Y, Saito S, Kioka H, Araki R, Asano Y, Takashima S, Sakata Y, Yoshioka Y
  • Journal Title: J Magn Reson Imaging. Volume: 51 Issue: 2 Pages: 563-570
  • DOI: 10.1002/jmri.26844
  • Peer Reviewed / Open Access
• [Journal Article] Noninvasive longitudinal quantification of β-cell mass with [111In]-labeled exendin-4. (2019)
  • Author(s): Fujita N, Fujimoto H, Hamamatsu K, Murakami T, Kimura H, Toyoda K, Saji H, Inagaki N
  • Journal Title: FASEB J. Volume: 33 Issue: 11 Pages: 11836-11844
  • DOI: 10.1096/fj.201900555RR
  • Peer Reviewed / Open Access
• [Journal Article] First prototyping of a dedicated PET system with the hemisphere detector arrangement. (2019)
  • Author(s): Hideaki Tashima, Eiji Yoshida, Yuma Iwao, Hidekatsu Wakizaka, Takamasa Maeda, Chie Seki, Yasuyuki Kimura, Yuhei Takado, Makoto Higuchi, Tetsuya Suhara, Taichi Yamashita, Taiga Yamaya
  • Journal Title: Phys Med Biol. Volume: 64 Issue: 6 Pages: 65004
  • DOI: 10.1088/1361-6560/ab012c
  • Peer Reviewed / Open Access
• [Journal Article] What does diagnostic threshold mean? Deterministic and probabilistic considerations. (2019)
  • Author(s): Nakajima K, Okuda K, Komatsu J.
  • Journal Title: J Nucl Cardiol.
  • DOI: 10.1007/s12350-019-01899-2
  • Peer Reviewed / Open Access
• [Journal Article] Demystifying dyssynchrony for diagnosis and prognosis : Tips for measuring heterogeneous phase distribution. (2019)
  • Author(s): Nakajima K, Okuda K, Maruyama K.
  • Journal Title: J Nucl Cardiol.
  • DOI: 10.1007/s12350-019-01855-0
  • Peer Reviewed / Open Access
• [Journal Article] Making the invisible visible-Phase dyssynchrony has potential as a new prognostic marker. (2019)
  • Author(s): Nakajima K, Okuda K, Matsuo S, Slomka P.
  • Journal Title: J Nucl Cardiol. Volume: 26 Pages: 298-302
  • DOI: 10.1007/s12350-017-0929-5
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Phase dyssynchrony and 123I-meta- iodobenzylguanidine innervation imaging towards standardization. (2019)
  • Author(s): Nakajima K, Okuda K, Verberne HJ.
  • Journal Title: J Nucl Cardiol. Volume: 26 Pages: 519-523
  • DOI: 10.1007/s12350-017-1069-7
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Beware the pitfalls of beauty : High-quality myocardial images with resolution recovery. (2019)
  • Author(s): Kenichi Nakajima, Hiroto Yoneyama, Piotr Slomka
  • Journal Title: J Nucl Cardiol.
  • DOI: 10.1007/s12350-019-01715-x
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Postconditioning Accelerates Myocardial Inflammatory Resolution Demonstrated by 14C-Methionine Imaging and Attenuates Ventricular Remodeling After Ischemia and Reperfusion. (2019)
  • Author(s): Junichi Taki, Anri Inaki, Hiroshi Wakabayashi, Ichiro Matsunari, Kyoko Imanaka-Yoshida, Kazuma Ogawa, Michiaki Hiroe, Kazuhiro Shiba, Seigo Kinuya
  • Journal Title: Circ J. Volume: 83 Issue: 12 Pages: 2520-2526
  • DOI: 10.1253/circj.CJ-19-0462
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Prognostic Value of Early Evaluation of Left Ventricular Dyssynchrony After Myocardial Infarction. (2019)
  • Author(s): Hiroshi Wakabayashi, Junichi Taki, Anri Inaki, Tomo Hiromasa, Takafumi Yamase, Norihito Akatani, Koichi Okuda, Takayuki Shibutani, Kazuhiro Shiba, Seigo Kinuya
  • Journal Title: Mol Imaging Biol. Volume: 21 Issue: 4 Pages: 654-659
  • DOI: 10.1007/s11307-018-1279-7
  • Peer Reviewed / Open Access
• [Journal Article] A novel amphipathic cell-penetrating peptide based on the N-terminal glycosaminoglycan binding region of human apolipoprotein E. (2019)
  • Author(s): Takashi Ohgita, Yuki Takechi-Haraya, Ryo Nadai, Mana Kotani, Yuki Tamura, Karin Nishikiori, Kazuchika Nishitsuji, Kenji Uchimura, Koki Hasegawa, Kumiko Sakai-Kato, Kenichi Akaji, Hiroyuki Saito
  • Journal Title: Biochimica et biophysica acta Biomembr. Volume: 1861 Issue: 3 Pages: 541-549
  • DOI: 10.1016/j.bbamem.2018.12.010
  • Peer Reviewed / Open Access
• [Journal Article] Shortened acquisition time in simultaneous 99mTc-tetrofosmin and 123I-β-methyl-p-iodophenyl pentadecanoic acid dual-tracer imaging with cadmium-zinc-telluride detectors in patients undergoing primary coronary intervention for acute myocardial infarction. (2019)
  • Author(s): Yamada Y, Nakano S, Gatate Y, Sugi K, Okano N, Muramatsu T, Nishimura S, Kuji I, Fukushima K, Matsunari I
  • Journal Title: Nucl Med Commun. Volume: 40 Issue: 11 Pages: 26-31
  • DOI: 10.1097/MNM.0000000000001084
  • Peer Reviewed / Open Access
• [Journal Article] Functional and metabolic improvement after coronary intervention for non-viable myocardium detected by 18F fluorodeoxyglucose positron emission tomography. (2019)
  • Author(s): Fukushima K, Arashi H, Minami Y, Nakao R, Nagao M, Abe K
  • Journal Title: J Cardiol Cases. Volume: 20 Issue: 2 Pages: 57-60
  • DOI: 10.1016/j.jccase.2019.03.006
  • Peer Reviewed / Open Access
• [Journal Article] Successful Bridge-to-Recovery Treatment in a Young Patient with Fulminant Eosinophilic Myocarditis : Roles of a Percutaneous Ventricular Assist Device and Endomyocardial Biopsy. (2019)
  • Author(s): Hasegawa-Tamba S, Sugi K, Gatate Y, Sugiyama K, Muramatsu T, Nishimura S, Yasuda M, Fukushima K, Nakano S
  • Journal Title: Case Rep Emerg Med. Pages: 8236735
  • DOI: 10.1155/2019/8236735
  • Peer Reviewed / Open Access
• [Journal Article] Stability of Distribution of F18 Flurpiridaz After Transient Coronary Occlusion in Pigs. (2019)
  • Author(s): Werner RA, Koshino K, Arimitsu K, Lapa C, Javadi MS, Rowe SP, Nose N, Kimura H, Fukushima K, Higuchi T.
  • Journal Title: JACC Cardiovasc Imaging. Volume: 12 Issue: 11Pt1 Pages: 2269-2271
  • DOI: 10.1016/j.jcmg.2019.05.018
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] [18F]FMISO PET/CT as a preoperative prognostic factor in patients with pancreatic cancer. (2019)
  • Author(s): Yamane T, Aikawa M, Yasuda M, Fukushima K, Seto A, Okamoto K, Koyama I, Kuji I
  • Journal Title: EJNMMI Res. Volume: 9 Issue: 1 Pages: 39
  • DOI: 10.1186/s13550-019-0507-8
  • Peer Reviewed / Open Access
• [Journal Article] Cardiac Methotrexate-Induced Lymphoproliferative Disorder. (2019)
  • Author(s): Kaneyuki D, Iguchi A, Tokunaga C, Fukushima K, Sato T, Nakajima H
  • Journal Title: Ann Thorac Surg. Volume: 108 Issue: 3 Pages: e157-e159
  • DOI: 10.1016/j.athoracsur.2019.01.065
  • Peer Reviewed / Open Access
• [Journal Article] Feasibility of simultaneous 99mTc-tetrofosmin and 123I-BMIPP dual-tracer imaging with cadmium-zinc-telluride detectors in patients undergoing primary coronary intervention for acute myocardial infarction. (2019)
  • Author(s): Yamada Y, Nakano S, Gatate Y, Okano N, Muramatsu T, Nishimura S, Kuji I, Fukushima K, Matsunari I
  • Journal Title: J Nucl Cardiol.
  • DOI: 10.1007/s12350-018-01585-9
  • Peer Reviewed / Open Access
• [Journal Article] Evaluation of transporter-mediated hepatobiliary transport of newly developed 18F-labeled pitavastatin derivative, PTV-F1, in rats by PET imaging. (2019)
  • Author(s): Kimura H, Yagi Y, Mikamo M, Maeda K, Kagawa S, Arimitsu K, Higashi T, Nishii R, Ono M, Nakamoto Y, Togashi K, Kusuhara H, Saji H
  • Journal Title: Drug Metab Pharmacokinet. Volume: 34 Issue: 5 Pages: 317-324
  • DOI: 10.1016/j.dmpk.2019.05.006
  • Peer Reviewed / Open Access
• [Journal Article] Synthesis and biological evaluation of Tc-99m-cyclopentadienyltricarbony1-technetium-labeled A-85380 : An imaging probe for single-photon emission computed tomography investigation of nicotinic acetylcholine receptors in the brain. (2019)
  • Author(s): Kimura H, Ueda M, Kawashima H, Arimitsu K, Yagi Y, Saji H
  • Journal Title: Bioorg Med Chem. Volume: 27 Issue: 11 Pages: 2245-2252
  • DOI: 10.1016/j.bmc.2019.04.030
  • Peer Reviewed / Open Access
• [Journal Article] Evaluation of [18F]pitavastatin as a positron emission tomography tracer for in vivo organic transporter polypeptide function. (2019)
  • Author(s): Yagi Y, Kimura H, Okuda H, Ono M, Nakamoto Y, Togashi K, Saji H
  • Journal Title: Nucl Med Biol. Volume: 74-75 Pages: 25-31
  • DOI: 10.1016/j.nucmedbio.2019.08.001
  • Peer Reviewed / Open Access
• [Journal Article] Reproducibility of Liver Magnetic Resonance Elastography (MRE)Measurement and Its Affecting Factors. (2019)
  • Author(s): Saito S
  • Journal Title: Nihon Hoshasen Gijutsu Gakkai Zasshi. Volume: 75 Issue: 12 Pages: 1484-1490
  • DOI: 10.6009/jjrt.2019_JSRT_75.12.1484
  • Peer Reviewed / Open Access
• [Journal Article] Neurite orientation dispersion and density imaging for evaluating the severity of neonatal hypoxic-ischemic encephalopathy in rats. (2019)
  • Author(s): Ohki A, Saito S, Hata J, Okano HJ, Higuchi T, Fukuchi K.
  • Journal Title: Magn Reson Imaging. Volume: 62 Pages: 214-219
  • DOI: 10.1016/j.mri.2019.07.013
  • Peer Reviewed / Open Access
• [Journal Article] Amide proton transfer imaging of glioblastoma, neuroblastoma, and breast cancer cells on a 11.7T magnetic resonance imaging system. (2019)
  • Author(s): Tanoue M, Saito S, Takahashi Y, Araki R, Hashido T, Kioka H, Sakata Y, Yoshioka Y
  • Journal Title: Magn Reson Imaging. Volume: 62 Pages: 181-190
  • DOI: 10.1016/j.mri.2019.07.005
  • Peer Reviewed / Open Access
• [Journal Article] How to Keep a Lab Notebook. (2019)
  • Author(s): Saito S
  • Journal Title: Nihon Hoshasen Gijutsu Gakkai Zasshi. Volume: 75 Issue: 8 Pages: 825-831
  • DOI: 10.6009/jjrt.2019_JSRT_75.8.825
• [Journal Article] Early detection of elevated lactate levels in a mitochondrial disease model using chemical exchange saturation transfer(CEST) and magnetic resonance spectroscopy (MRS) with 7T MR imaging. (2019)
  • Author(s): Saito S, Takahashi Y, Ohki A, Shintani Y, Higuchi T
  • Journal Title: Radiol Phys Technol. Volume: 12 Issue: 2 Pages: 232-233
  • DOI: 10.1007/s12194-019-00510-0
  • Peer Reviewed / Open Access
• [Journal Article] Detection of increased intracerebral lactate in a mouse model of Leigh syndrome using proton MR spectroscopy. (2019)
  • Author(s): Takahashi Y, Kioka H, Shintani Y, Ohki A, Takashima S, Sakata Y, Higuchi T, Saito S
  • Journal Title: Magn Reson Imaging. Volume: 58 Pages: 38-43
  • DOI: 10.1016/j.mri.2019.01.010
  • Peer Reviewed / Open Access
• [Journal Article] Looking Back on the 10th Anniversary of Radiological Physics and Technology(RPT). (2019)
  • Author(s): Doi K, Kodera Y, Sanada S, Shiraishi J, Saito S.
  • Journal Title: Nihon Hoshasen Gijutsu Gakkai Zasshi. Volume: 75 Issue: 1 Pages: 1-12
  • DOI: 10.6009/jjrt.2019_JSRT_75.1.1
  • Peer Reviewed / Open Access
• [Journal Article] Roles of the Mesenchymal Stromal/Stem Cell Marker Meflin in Cardiac Tissue Repair and the Development of Diastolic Dysfunction. (2019)
  • Author(s): Hara A, Kobayashi H, Asai N1, Saito S, Higuchi T, Kato K, Okumura T, Bando YK, Takefuji M, Mizutani Y, Miyai Y, Saito S, Maruyama S, Maeda K, Ouchi N, Nagasaka A, Miyata T, Mii S, Kioka N, Worthley DL, Murohara T, Takahashi M, Enomoto A
  • Journal Title: Circ Res. Volume: 125 Issue: 4 Pages: 414-430
  • DOI: 10.1161/CIRCRESAHA.119.314806
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Metabolic substrate shift in human induced pluripotent stem cells during cardiac differentiation : Functional assessment using in vitro radionuclide uptake assay. (2018)
  • Author(s): Naoko Nose, Rudolf A Werner, Yuichiro Ueda, Katharina Günther, Constantin Lapa, Mehrbod S Javadi, Kazuhito Fukushima, Frank Edenhofer, Takahiro Higuchi
  • Journal Title: Int J Cardiol. Volume: 269 Pages: 229-234
  • DOI: 10.1016/j.ijcard.2018.06.089
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 18 F-Labeled Derivatives of Irbesartan for Angiotensin Ⅱ Receptor PET Imaging. (2018)
  • Author(s): Hoffmann M, Chen X, Hirano M, Arimitsu K, Kimura H, Higuchi T, Decker M
  • Journal Title: ChemMedChem. Volume: 13 Issue: 23 Pages: 2546-2557
  • DOI: 10.1002/cmdc.201800638
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] 最新ドイツ事情 : 前立腺癌の放射能標識PSMA 標的診断・療法の夜明け (2020)
  • Author(s): 樋口 隆弘
  • Organizer: 第322回日本泌尿器科学会 岡山地方会
  • Invited
• [Presentation] In vivo イメージング技術を用いた投与細胞体内動態評価 (2019)
  • Author(s): 樋口 隆弘
  • Organizer: 日本薬物動態学会 第34回年会-第13回日本薬物動態学会ショートコース
  • Invited
• [Presentation] 不全心筋の微小循環障害 (2019)
  • Author(s): 樋口 隆弘
  • Organizer: 第29回 日本心臓核医学学会総会・学術大会
  • Invited
• [Presentation] Machine Learning Model for Predicting Sudden Cardiac Death and Heart Failure Death Using 123I-meta-iodobenzylguanidine. (2019)
  • Author(s): Nakajima K, Nakata T, Matsuo S, Doi T, Jacobson AF
  • Organizer: International Conference of Nuclear Cardiology and cardiac CT 2019
  • Int'l Joint Research
• [Presentation] Differential prediction of heart failure death and arrhythmic death using machine learning model and Ⅰ-123 metaiodobenzylguanidine. (2019)
  • Author(s): Nakajima K, Nakata T, Doi T, Matsuo S
  • Organizer: SNMMI2019
  • Int'l Joint Research
• [Presentation] Abnormal Ⅰ-123 MIBG scan can be identified by artificial neural network : possible application to Lewy body diseases. (2019)
  • Author(s): Nakajima K, Watanabe S, Maruyama K, Inaki A, Wakabayashi H, OKuda K, Kinuya S.
  • Organizer: EANM2019
  • Int'l Joint Research
• [Presentation] Prediction of cardiac death using 123I-MIBG : comparison between statistical and machine learning models for serious arrhythmic events and heart failure death. (2019)
  • Author(s): Nakajima K, Nakata T, Doi T, Maruyama K.
  • Organizer: EANM2019
  • Int'l Joint Research
• [Presentation] Colchicine Attenuates Myocardial Inflammatory Response and Ventricular Remodeling after Acute Myocardial Infarction Demonstrated by C-14-methionine Imaging and Gated SPECT. (2019)
  • Author(s): Taki J, Wakabayashi H, Matsunari I, Imanaka-Yoshida K, Hiroe M
  • Organizer: 第83回日本循環器学会学術集会
  • Int'l Joint Research
• [Presentation] 基礎から学ぶ・虚血評価モダリティ 運動・薬剤負荷心筋シンチグラム (2019)
  • Author(s): 瀧 淳一
  • Organizer: Functional Revascularization Encouraged by optomal Diagnostic Strategy Live 2019
  • Invited
• [Presentation] 急性梗塞後のC-14メチオニンイメージング、抗炎症薬投与と左室リモデリングの検討 (2019)
  • Author(s): 瀧 淳一、若林大志、稲木杏吏、森 博史、廣正 智、赤谷憲一、山瀬喬史、小川数馬、柴 和弘、松成一朗、絹谷清剛
  • Organizer: 第59回日本核医学会学術総会
  • Int'l Joint Research
• [Presentation] Examination of radioisotope labeling methods with 18F-FDG for in vivo T-cell tracking (2019)
  • Author(s): 太田峻矢、能勢直子、野上俊、嘉島相輝、河本宏、福地一樹、樋口隆弘
  • Organizer: 第59回日本核医学会学術総会
  • Int'l Joint Research
• [Presentation] Multiple-World Genetic Algorithm to Identify Locally Reasonable Behaviors in Complex Social Networks (2019)
  • Author(s): Yutaro Miura, Fujio Toriumi, Toshiharu Sugawara
  • Organizer: 2019 IEEE International Conference on Systems, Man and Cybernetics
  • Int'l Joint Research
• [Presentation] Multiple World Genetic Algorithm to Analyze Individually Advantageous Behaviors in Complex Networks (2019)
  • Author(s): Yutaro Miura, Fujio Toriumi, Toshiharu Sugawara
  • Organizer: GECCO2019
  • Int'l Joint Research
• [Presentation] 国内未承認RI内用療法に関する海外動向ならびに国内導入に向けた臨床サイドから見たニーズ・問題点に関する調査研究 (2018)
  • Author(s): 福島 和人, 高野 祥子, 長谷川 功紀, 野上 宗伸, 日向 信之, 樋口 隆弘
  • Organizer: 第58回日本核医学会学術総会
  • Int'l Joint Research
• [Book] 僕らのAI論9名の識者が語る人工知能と「こころ」 (2019)
  • Author(s): 森川幸人・松原仁・一倉宏・伊藤毅志・鳥海不二夫・三宅陽一郎・糸井重里・近藤那央・山登敬之・中野信子
  • Total Pages: 216
  • Publisher: サイエンス・アイ新書
• [Funded Workshop] The 1st International Collaborative Research Meeting in Naoshima (2019)