2007 Fiscal Year Final Research Report Summary
Tailor-made NK4-gene therapy for pancreatic cancer using nano devise.
| Project/Area Number |
16209040
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
TANAKA Masao Kyushu University, Department of surgery and clinical oncology, Professor (30163570)
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| Co-Investigator(Kenkyū-buntansha) |
MIZUMOTO Kazuhiro Kyushu University, Hospital, Cancer Center, Associate Professor (90253418)
NAGAI Eishi Kyushu University, Hospital, First department of surgery, Associate Professor (30264021)
NAKAMURA Toshikazu Osaka University, Graduate School of Medicine, Department of Biochemistry and Molecular Biology, Professor (00049397)
MATSUMOTO Kunio Osaka University, Graduate School of Medicine, Department of Biochemistry and Molecular Biology, Associate Professor (90201780)
ONA Toshihiro KYUSHU UNIVERSITY, Faculty of Agriculture, Department of Forest Chemistry and Forest Products Sciences, Associate Professor (10346835)
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| Project Period (FY) |
2004 – 2007
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| Keywords | Pancreatic cancer / NK4 / HGF / drug delivery system / adenovirus / gene therapy |
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| Research Abstract |
We performed preclinical studies to establish the novel gene therapy for pancreatic cancer using adenovirus expressing NK4, which is antagonist of HGF.
We confirmed the safety of adno-NK4 using animal models. (2) We investigated the effect of combination therapy with gemcitabine and adeno-NK4 and demonstrated that synergistic effect of this therapy. (3)We revealed that trans-portal adeno-NK4 administration significantly inhibited the liver metastasis of pancreatic cancer in mouse models. (4) We developed novel drug delivery system using cell-sheet expressing NK4 and showed that the novel DDS controlled local progression of pancreatic cancer in mouse models. (5)We found the novel inhibitory effect of combination therapy with gemcitabine and fibrin glue and performed and continued the clinical trials using this therapy. (6) We developed rapid diagnostic system for pancreatic juice samples. (7.8) We clarified the mechanism of adenovirus-based gene therapy enhanced by gemcitabine or radiation.(9)We found that tert-promotor-medated CRAds therapy was also enhanced by gemcitabine or other anticancer agents.
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Research Products
(63 results)
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[Presentation] Implication of S100P in pancreatic cancer as an early developmental marker and a therapeutic target2006
Author(s)
Ohuchida, k., Mizumoto, k., Konomi, H., Nagai, E., Yamaguchi, K., Tanaka M
Organizer
DDW
Year and Date
20060000
Description
「研究成果報告書概要(欧文)」より
-
[Presentation] Implication of S100P in pancreatic cancer as an early developmental marker and a therapeutic target2006
Author(s)
Ohuchida, k., Mizumoto, k., Konomi, H., Nagai, E., Yamaguchi, K., Tanaka, M.
Organizer
DDW
Year and Date
20060000
Description
「研究成果報告書概要(欧文)」より
-
[Presentation] Quantitative Analysis of hTERT mRNA in Pancreatic Juice Is More Useful for Differentiating Pancreatic Cancer from IPMN than from Chronic Pancreatitis2006
Author(s)
Ohuchida, k., Mizumoto, k., Konomi, H., Nagai, E., Yamaguchi, K., Tanaka M
Organizer
DDW
Year and Date
20060000
Description
「研究成果報告書概要(欧文)」より
-
[Presentation] Twist a novel oncogene, is up-regulated in pancreatic cancer ; clinical implication of Twist expression in pancreatic juice2006
Author(s)
Ohuchida, k., Mizumoto, k., Konomi, H., Nagai, E., Yamaguchi, K., Tanaka M
Organizer
DDW
Year and Date
20060000
Description
「研究成果報告書概要(欧文)」より
-
[Presentation] Differential expressions of mRNA2006
Author(s)
Ohuchida, K., Yamaguchi, H., Nagai, E., Tsuneyoshi, M., Tanaka M
Organizer
American Pancreatic Association & ; International Association of Pancreatology
Year and Date
20060000
Description
「研究成果報告書概要(欧文)」より
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-
[Presentation] Significance of Phosphorylation of Chk2 in Intraductal Papillary Mucinous Neoplasms of the Pancreas2006
Author(s)
Miyasaka, Y., Nagai, E., Yamaguchi, H., Fujii, K., Inoue, T., Ohuchida, K., Mizumoto, K., Tsuneyoshi, M., Tanaka M
Organizer
American Pancreatic Association & ; International Association of Pancreatology
Year and Date
20060000
Description
「研究成果報告書概要(欧文)」より
-
[Presentation] The role of S100 family as diagnostic marker and therapeutic target in pancreatic cancer2005
Author(s)
Mizumoto, K., Ohuchida, K., Konomi, H., Nagai, E., Yamaguchi, K., Tanaka M
Organizer
15th World Congress of the International Association of Surgeons and Gastroenterologists
Year and Date
20050000
Description
「研究成果報告書概要(欧文)」より
