2007 Fiscal Year Final Research Report Summary
Integrate research of genomics and proteomics of novel molecular targets for development of periodontal diseases cure
| Project/Area Number |
16209063
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
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| Research Institution | Nihon University |
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Principal Investigator |
ABIKO Yoshimitsu Nihon University, School of Dentistry at Matsudo, Professor (70050086)
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| Co-Investigator(Kenkyū-buntansha) |
KURIHARA Hidemi Hiroshima University, Graduate School of Biomedical Sciences, Professor (40161765)
MURAKAMI Shinya Osaka University, Graduate School of Dentistry, Professor (70239490)
NAKAYAMA Koji Nagasaki University, Graduate School of Biomedical Sciences, Professor (80150473)
AMANO Atsuo Osaka University, Graduate School of Dentistry, Professor (50193024)
TAKASHIBA Shogo Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Professor (50226768)
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| Project Period (FY) |
2004 – 2007
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| Keywords | Periodontal Research / Development of treatment / Genomics / Proteomics / Transcriptomics / GeneChip / Target molecules |
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| Research Abstract |
Experimental research utilizing functional genomics technologies with DNA/protein database will serve to identification of genes and their expressions on the transcriptional level exemplify their utility for the understanding the life science. Several bacterial genome projects associated with oral infectious diseases are in progress. Human genome has been sequenced and assembled, making the accessible for genetic studies in near future. Recently, technological advances, such as subtractive gene cloning and DNA microarray, have been applied to discover of novel genes involved in complex metabolism. For example, since little is known regarding the molecules expressed by gingival epithelial cells that are involved in inflammation following the interaction with periodontal pathogens, to find transcriptional profiling of genes in human gingival epitherial cells in response to LPS, we examined many altered gene expressions using over 8,000 cDNA microarray (Incyte, GEM). To find transcriptional profiles of genes in submandibular gland by ageing, we examined mRNA levels of over 6,500 genes by nucleotide micreoarray (Affimetrix, GeneChip). Our laboratory involved in dental science projects using these technologies and genome database. By this Grant support, we plan to make the new database for oral diseases, which will be used easily by many researchers. The genome project and molecular biological approaches using the database will open the gate develop the dental science.
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Research Products
(67 results)
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[Presentation] Yorimasa Ogata Insulin-likeGrowthFactor-IRegulates Bone SialoproteinGene Expression2007
Author(s)
Youhei, Nakayama, Naoko, Kato, Hideki, Takai, Dong-Soon, Kim, Masato, Arai, Shouta, Araki, Masaru, Mezawa
Organizer
9th International Conference of Chemistry and Biology of Mineralized Tissues
Place of Presentation
Austin USA
Year and Date
20071104-08
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Regulation of Human Bone Sialoprotein Gene Transcription by Platelet-derived Growth Factor2007
Author(s)
Masaru, Mezawa, Shouta, Araki, Dong-Soon, Kim, Hideki, Takai, Zhitao, Wang, Xinyue, Li, Naoko, Kato, Youhei, Nakayama, Yorimasa, Ogata
Organizer
9th International Conference of Chemistry and Biology of Mineralized Tissues
Place of Presentation
Austin USA
Year and Date
20071104-08
Description
「研究成果報告書概要(欧文)」より
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[Presentation] PTH regulates Human Bone Sialoprotein Gene Transcription2007
Author(s)
Shouta, Araki, Youhei, Nakayama, Naoko, Kato, Hideki, Takai, Hong-Soon, Kim, Zhengyang, Li, Li, Yang, Masaru, Mezawa, Yorimasa, Ogata
Organizer
9th International Conference of Chemistry and Biology of Mineralized Tissues
Place of Presentation
Austin USA
Year and Date
20071104-08
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Regulaton of BSP Gene Transcription by Amelogenins and Sheath Proteins2007
Author(s)
Yorimasa, Ogata, Yu, Nakajima, Li, Yang, Zhengyang, Li, Zhitao, Wang, Xinyue, Li, Masaru, Mezawa, Shouta, Araki, Youhei, Nakayame, Shinichiro, Oida, Makoto, Fukae
Organizer
9th International Conference of Chemistry and Biololgy of Mineralized Tissues
Place of Presentation
Austin USA
Year and Date
20071104-08
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Effect of genotypes of Porphyromonas gingivalis fimbriae on biofilm formation2007
Author(s)
Kuboniwa, M., Amano, A., Kato, T., Iwasaki, M., Hashino, E., Shizukuishi, S
Organizer
55th Annual Meeting of Japanese Association for Dental Research
Place of Presentation
Yokohama
Year and Date
2007-11-17
Description
「研究成果報告書概要(欧文)」より
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