Establishment of delivery system to the brain for antilsodies, enzymes, and neurotrophic factors without breakage of blood-brain barrier

2007 Fiscal Year Final Research Report Summary

• Project/Area Number: 16300121
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: Nagoya University
• Principal Investigator: SAWADA Makoto Nagoya University, Research Institute of Environmental Medicine, Professor (10187297)
• Co-Investigator(Kenkyū-buntansha): ONO Kenji Nagoya University, Research Institute of Environmental Medicine, Assistant prof (80329698)
• Project Period (FY): 2004 – 2007
• Keywords: microglia / brain-targeting molecule / chemical conjugates / brain-targeting tag

Research Abstract

It is known that a certain kind of cells can migrate into a specific target organ from blood flow when injected. They include brain-migrating cells such as neural stem cells, a part of bone marrow derived cells, lymphocytes and microglia. Microglia are subpopulation of glial cell in the brain and play important roles in the development, differentiation and maintenance of neural cells via their phagocytic activity and production of enzymes, cytokines and trophic factors. The mechanism of microglial brain migration is thought to be via a trans cellular pathway because microglial migration occur with out any breakage of the blood brain barrier. I found that microglia clone cells retain the capability to migrate into the brain from the circulation and that microglia can deliver the gene of interest to brain, by injecting microglia transfected galactosidase gene expressing vector to the circulation.
Meanwhile, I have successfully isolated several peptide which can mimic and/or compete the microglial brain-migrating activity. The peptides are small enough to be attached to several chemicals and biochemical materials and also to put in the sequence franking to recombinant protein as a brain-migrating tag. I indicated the ability of the peptides to penetrate through the BBB and distribute in brain parenchyma, therefore, the modified peptides are useful for the multi-purpose delivery tool to the brain, an availability of which was proved by several analyses including in vivo PET imaging.
Now I and my colleagues are trying to produce several brain-targeting drugs with our novel peptide. Our peptides may open the way of delivering into brain parenchyma even a compound as the PET-ligand with poor penetrability into brain. Further, we expect that our peptides offer the more flexibility in use for the delivery of many bio active materials into the brain.

Research Products

• [Journal Article] Early and late activation of the voltage-gated proton channel during lactic acidosis through pH-dependent and -independent mechanisms. (2008)
  • Author(s): MORIHATA H, KAWAWAKI J, OKINA M, SAKAI H, NOTOMI T, SAWADA M, KUNO M
  • Journal Title: Pflugers Archiv-European Journal of Physiology 455(5) Pages: 829-838
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Stimulus dependent regulation of the phagocyte NADPH oxidase by a VAV1, rac 1, and PAK1 signaling axis. (2008)
  • Author(s): Roepstorff K, Rasmussen I, SAWADA M, Cudre-Maroux Cr, Salomon Pa, Bokoch G, Van D B, Vihardt F
  • Journal Title: The Journal of Biological Chemistry 283(12): Pages: 7983-7993
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Early and late activation of the voltage-gated proton channel during lactic acidosis through pH-dependent and -independent mechanisms (2008)
  • Author(s): MORIHA, H, ICAWAWAKI, T, OKINA, M, SAKAI, H, NOTOMI, T, SAWADA, M, KUNO, M
  • Journal Title: Pflugers Archiv-European Journal of Physiology 455(5) Pages: 829-838
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Stimulus dependent regulation of the phagocyte NADPH oxidase by a VAV1, rac 1, and PAK1 signaling axis (2008)
  • Author(s): Roepstorff, K, Rasmussen, I, SAWADA, M, Cudre-Maroux, Cr, Salomon, Pa, Bokoch, G, Van, D B, Vihardt, F
  • Journal Title: The Journal of Biological Chemistry 283(12) Pages: 7983-7993
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effects of aging on neuropro-tective and neurotoxic properties of microglia in neurodegenerative diseases (2008)
  • Author(s): SAWADA, M, SAWADA, H, NAGATSU, T
  • Journal Title: Neuro-degenerative Diseases 5(3-4) Pages: 254-256
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effects of aging on neuroprotective and neurotoxic properties of microglia in neurodegenerative diseases. (2007)
  • Author(s): SAWADA M, SAWADA H, NAGATSU T
  • Journal Title: Neuro-degenerative Diseases (3-4) Pages: 254-256
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Phosphatidylserine and phosphatidylcholine-containing liposomes inhibit amyloid beta and interferon-gamma-induced microglial activation (2007)
  • Author(s): HASHIOKA S, YOUN-Hee Han, FUJII S, KATO T, MONJI A, UTSUMI H, SAWADA M, NAKANISHI H, KANBA S
  • Journal Title: Free Radical Biology & Medicine 42(7) Pages: 945-954
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] The effects of general anesthetics on P2X7 and P2Y receptors in a rat microglial cell line. (2007)
  • Author(s): NAKANISHI M, MORI T, NISHIKAWA K, SAWADA M, KUNO M, ASADA A
  • Journal Title: Anesthesia and Analgesia 104(5) Pages: 1136-1144
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Induction of matrix mettaloproteinases(MMP3,MMP12 and MMP13)expression in the microglia by Amyloidbeta stimulation via the PI3K/Akt pathway. (2007)
  • Author(s): ITO S, KIMURA K, HANEDA M, ISHIDA Y, SAWADA M, ISOBE K
  • Journal Title: Experimental Gerontology 85(8) Pages: 1752-1761
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Activated microglia affect the nigro-striatal dopamine neurons differently in neonatal and aged mice treated with l-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine. (2007)
  • Author(s): SAWADA H, HASHIDA R, HIRATA Y, ONO K, SUZUKI H, MURAMATSU S, NAKANOI, NAGATSU T, SAWADA M
  • Journal Title: Journal of Neuroscience Research 85(8) Pages: 1752-1761
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Antidepressants Inhibit interferon-gamma-induced microglial production of IL-6 and nitric oxide. (2007)
  • Author(s): HASHIOKA S, KLEGERIS A, MONJI A, KATO T, SAWADA M, McGeer P L, KANBA S
  • Journal Title: Experimental Neurology 206(1) Pages: 33-42
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] N-Benzy1-2-(6, 8-dichloro-2-(-(4-chlorophenyl)imidazo[1, 2-a lpyridin-3-yl]-N-(6-(7-nitrobenzo[c][1, 2, 5]oxadiazol-4-ylamino)hexyl)acetamide as a New Fluorescent Probe for Peripheral Benzodiazepine Receptor and Microglial Cell Visualization. (2007)
  • Author(s): Valentino L, Nunzio D, Angela L, SUZUKI H, SAWADA M, Mariangela S, Giovanni B, Andrea L, Giuseppe T, Gaetano L
  • Journal Title: Bioconjugate Chemistry. 18(5) Pages: 1397-1407
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Biochemistry of postmortem brains in Parkinson's disease: historical overview and future prospects. (2007)
  • Author(s): NAGATSU T, SAWADAM
  • Journal Title: Journal of Neural Transmission Supplement 72 Pages: 113-120
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Molecular mechanism of the relation of monoamine oxidase B and its inhibitors to Parkinson's disease: possible implications of glial cells. (2007)
  • Author(s): NAGATSU T, SAWADA M
  • Journal Title: Journal of Neural Transmission-Supplement 71 Pages: 53-65
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Phospholipids modulate superoxide and nitric oxide production by lipopolysaccharide and phorbol 12-myristate-13-acetate-activated microglia (2007)
  • Author(s): HASHIOKA S, HAN Youn-H, FUJII S, KATO T, MONJI A, UTSUMI H, SAWADA M, NAKANISHI H, KANBA S:
  • Journal Title: Neurochemistry International 50(3) Pages: 499-506
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Targeting and imaging of brain-specific cell migration. (2007)
  • Author(s): SAWADA M, ONO K, SUZUKIH
  • Journal Title: Nippon Rinsho 65(2) Pages: 213-218
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Neuroprotective effect of exogenous microglia in global ischemia. (2007)
  • Author(s): IMAI F, SUZUKI H, ODA J, NINOMIYA T, ONO K, SANOH, SAWADA M
  • Journal Title: Journal of Cerebral Blood Flow & Metabolism 27(3) Pages: 488-500
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Phosphatidylserine and phosphatidylcholine-containing liposomes inhibit amyloid beta and interferon-gamma-induced microglial activation (2007)
  • Author(s): HASHIOKA, S, YOUN-Hee, Han, FUJII, S, KATO, T, MONJI, A, UTSUMI, H, SAWADA, M, NAKANISHI, H, KANBA, S
  • Journal Title: Free Radical Biology & Medicine 42(7) Pages: 945-954
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The effects of general anesthetics on P2X7 and P2Y receptors in a rat microglial cell line (2007)
  • Author(s): NAKANISHI, M, MOM, T, NISHIKAWA, K, SAWADA, M, KUNO, M, ASADA, A
  • Journal Title: Anesthesia and Analgesia 104(5) Pages: 1136-1144
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Induction of matrix mettaloproteinases(MMP3, MMP12 and MMP13) expression in the microglia by Amyloidbeta stimulation via the PI3K/Akt pathway (2007)
  • Author(s): ITO, S, KIMURA, K, HANEDA, M, ISHIDA, Y, SAWADA, M, ISOBE, K
  • Journal Title: Experimental Gerontology 42(6) Pages: 532-537
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Activated microglia affect the nigro-striatal dopamine neurons differently in neonatal and aged mice treated with 1-methyl-4-phenyl-1,2,3, 6- tetrahydropyridine (2007)
  • Author(s): SAWADA, H, HASHIDA, R, ERRATA, Y, ONO, K, SUZUKI, H, MURAMATSU, S, NAKANO, I, NAGATSU, T, SAWADA, M
  • Journal Title: Journal of Neuroscience Research 85(8) Pages: 1752-1761
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Antidepressants Inhibit interferon-gamma-induced microglial production of IL-6 and nitric oxide (2007)
  • Author(s): HASHIOKA, S, KLEGERIS, A, MONJI, A, KATO, T, SAWADA, M, McGeer, PL, KANBA, S
  • Journal Title: Experimental Neurology 206(1) Pages: 33-42
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] N-Benzyl-2-(6,8-dichloro-2-((4-chlorophenyl) irnidazo[1,2-alpyridin-3-yl]-N-(6-(7-nitrobenzo[c][1,2,5]oxadiazol-4-ylamino) hexyl)acetamide as a New Fluorescent Probe for Peripheral Benzodiazepine Receptor and Microglial Cell Visualization (2007)
  • Author(s): Valentino, L, Nunzio, D, Angela, L, SUZUKI, H, SAWADA, M, Mariangela, S, Giovanni, B, Andrea, L, Giuseppe, T, Gaetano, L
  • Journal Title: Bioconjugate Chemistry 18(5) Pages: 1397-1407
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Biochemistry of postmortem brains in Parkinson's disease : historical overview and future prospects (2007)
  • Author(s): NAGATSU, T, SAWADA, M
  • Journal Title: Journal of Neural Transmission Supplement 72 Pages: 113-120
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Molecular mechanism of the relation of monoamine oxidase B and its inhibitors to Parkinson's disease : possible implications of glial cells (2007)
  • Author(s): NAGATSU, T, SAWADA, M
  • Journal Title: Journal of Neural Transmission-Supplement 71 Pages: 53-65
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Phospholipids modulate superoxide and nitric oxide production by lipopolysaccharide and phorbol 12-myristate-13-acetate-activated microglia (2007)
  • Author(s): HASHIOKA, S, HAN, Youn-H, FUJII, S, KATO, T, MONJI, A, UTSTJMI, H, SAWADA, M, NAKANISHI, H, KANBA, S
  • Journal Title: Neurochemistry International 50(3) Pages: 499-506
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Targeting and imaging of brain-specific cell migration (2007)
  • Author(s): SAWADA, M, ONO, K, SUZUKI, H
  • Journal Title: Nippon Rinsho 65(2) Pages: 213-218
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Neuroprotective effect of exogenous microglia in global ischemia (2007)
  • Author(s): IMAI, F, SUZUKI, H, ODA, J, NINOMIYA, T, ONO, K, SANO, H, SAWADA, M
  • Journal Title: Journal of Cerebral Blood Flow & Metabolism 27(3) Pages: 488-500
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Cellular and Molecular Mechanisms of Parkinson' s Disease: Neurotoxins, Causative Genens, and Inflammatory Cytokines. (2006)
  • Author(s): NAGATSU T, SAWADA M
  • Journal Title: Cellular and Molecular Neurobiology 26(4-6) Pages: 781-802
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Molecular pathologies of and enzyme replacement therapies for lysosomal diseases. (2006)
  • Author(s): SAKURABA H, SAWADA M, MATSUZAWA F, AIKAWA S, CHIBA Y, JIGAMI Y, ITOU K
  • Journal Title: Neurological Disorders-Drug Targets 5(4) Pages: 401-413
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] The intra-arterial injection of microglia protects hippocampal CAI neurons against global ischemia-induced functional deficits in rats. (2006)
  • Author(s): HAYASHI Y, TOMIMATSU Y, SUZUKI H, YAMADA J, WU Ziqiang, YAO Hngping, KAGAMIISHI Y, TATEISHI N, SAWADA M, NAKANISHI H
  • Journal Title: Neuroscience 142(1) Pages: 87-96
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Cell cycle-dependent regulation of kainate-induced inward currents in microglia. (2006)
  • Author(s): YAMADA J, SAWADA M, NAKANISHI H
  • Journal Title: Biochemical and Biophysical Research Communications 349(3) Pages: 913-919
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Amyloid-beta peptides induce several chemokine mRNA expressions in the primary microglia and Ra2 cell line via PI3K/Akt and/or ERK pathway. (2006)
  • Author(s): ITO S, SAWADA M, HANEDA M, ISHIDA Y, ISOBE K
  • Journal Title: Neuroscience Research 56(3) Pages: 294-299
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Role of cytokines in inflammatory process in Parkinson' s disease. (2006)
  • Author(s): SAWADA M, IMAMURA K, NAGATSU T
  • Journal Title: Journal of Neural Transmission Supplement 70 Pages: 373-381
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Cellular and Molecular Mechanisms of Parkinson's Disease : Neurotoxins, Causative Genens, and Inflammatory Cytokines (2006)
  • Author(s): NAGATSU, T, SAWADA, M
  • Journal Title: Cellular and Molecular Neurobiology 26(4-6) Pages: 781-802
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Molecular pathologies of and enzyme replacement therapies for lysosomal diseases (2006)
  • Author(s): SAKURABA, H, SAWADA, M, MATSUZAWA, F, AIKAWA, S, CHIBA, Y, JIGAMI, Y, ITOU, K
  • Journal Title: CNS & Neurological Disorders-Drug Targets 5(4) Pages: 401-413
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The intra-arterial injection of microglia protects hippocampal CAI neurons against global ischemia-induced functional deficits in rats (2006)
  • Author(s): HAYASHI, Y, TOMIMATSU, Y, SUZUKI, H, YAMADA, J, WU, Ziqiang, YAO, Hngping, KAGAMIISHI, Y, TATEISHI, N, SAWADA, M, NAKANISHI, H
  • Journal Title: Neuroscience 142(1) Pages: 87-96
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Cell cycle-dependent regulation of kainate-induced inward currents in microglia (2006)
  • Author(s): Yamada, J, Sawada, M, Nakanishi, H
  • Journal Title: Biochemical and Biophysical Research Communications 349(3) Pages: 913-919
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Amyloid-beta peptides induce several chemokine mRNA expressions in the primary microglia and Ra2 cell line via PI3K/Akt and/or ERIC pathway (2006)
  • Author(s): ITO, S, SAWADA, M, HANEDA, M, ISHIDA, Y, ISOBE, K
  • Journal Title: Neuroscience Research 56(3) Pages: 294-299
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Role of cytokines in inflammatory process in Parkinson's disease (2006)
  • Author(s): SAWADA, M, IMAMURA, K, NAGATSU, T
  • Journal Title: Journal of Neural Transmission Supplement 70 Pages: 373-381
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Rabies virus-induced activation of MAPK and NF-kappaB signaling pathways regulates expression of CXC and CC chemokine ligands in microglia. (2005)
  • Author(s): NAKAMICHI K, SAIKI M, SAWADA M, YAMAMURO Y, MORIMOTO K, KURANE I
  • Journal Title: Journal of Virology 79 Pages: 11801-11812
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Double-stranded RNA stimulates chemokine expression in microglia through vacuolar pH-dependent activation of intracellular signaling pathways. (2005)
  • Author(s): NAKAMICHI K, SAIKI M, SAWADA M, TAKAYAMA-ITO M, YAMAMURO Y, MORIMOTO K, KURANE I
  • Journal Title: Journal of Neurochemistry 95 Pages: 273-283
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Vitamin K2 ameliorates experimental autoimmune encephalomyelitis in Lewis rats. (2005)
  • Author(s): MORIYA M, NAKATSUJI Y, OKUNO T, HAMASAKI T, SAWADA M, SAKODA S
  • Journal Title: Journal of Neuroimmunology 170(1-2) Pages: 11-20
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] A lentiviral expression system demonstrates that L^* protein of Theiler's murine encephalomyelitis virus(TMEV)has an anti-apoptotic effect in amacrophage cell line. (2005)
  • Author(s): HIMEDA T, OHARA Y, ASAKURA K, KONTANI Y, SAWADA M
  • Journal Title: Microb Pathogenesis 38(5-6) Pages: 201-207
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Peripheral injection of lipopolysaccharide enhances expression of inflammatoty cytokins in murine locus coeruleus: possible role of increased norepinephrine turnover. (2005)
  • Author(s): KANEKO Y S, MORI K, NAKASHIMA A, SAWADA M, NAGATSU I, OTA A
  • Journal Title: Journal of Neurochemistry 94(2) Pages: 393-340
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Tonic-clonic seizures induce division of neuronal progenitor cells with concomitant changes in expression of neurotrophic factors in the brain of pilocarpine-treated mice. (2005)
  • Author(s): HAGIHARA H, HARA M, TSUNEKAWA K, NAKAGAWA Y, SAWADA M, NAKANO K
  • Journal Title: Molecular Brain Research 139(2) Pages: 258-266
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Inhibition of inflammatory cytokine secretion from mouse microglia cells by DHMEQ, an NF-kappaB inhibitor. (2005)
  • Author(s): TAKATSUNA H, MORITA S, NAGATSU T, SAWADA M, UMEZAWA K
  • Journal Title: Biomedecine & Pharmacotherapy 59(6) Pages: 318-322
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Inflammatory process in Parkinson's disease: role for cytokines. (2005)
  • Author(s): NAGATSU T, SAWADA M
  • Journal Title: Current Pharmceutical Design 11 Pages: 999-1016
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Cytokine production of activated microglia and decrease in neurotrophic factors of neurons in the hippocampus of Lewy body disease brains. (2005)
  • Author(s): IMAMURA K, HISHIKAWA N, ONO K, SUZUKI H, SAWADA M, NAGATSU T, YOSHIDA M, HASHIZUME Y
  • Journal Title: Acta Neuropathologica 109 Pages: 141-150
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Amyloid-beta peptides induce cell proliferation and macrophage colony-stimulating factor expression via the PI3-kinase/Akt pathway in cultured Ra2 microglial cells. (2005)
  • Author(s): ITO S, SAWADA M, HANEDA M, FUJII S, OHHASHI K, KIUCHI K, TAKAHASHI M, ISOBE K
  • Journal Title: FEBS Letters 579 Pages: 1995-2000
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] A lentiviral expression system demonstrates that L* protein of Theiler's murine encephalomyelitis virus(TMEV)is essential for virus growth in a murine macrophage-like cell line. (2005)
  • Author(s): HIMEDA T, OHARA Y, ASAKURA K, KONTANI Y, MURAKAMI M, SUZUKI H, SAWADA M
  • Journal Title: Virus Research 108 Pages: 23-28
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Localization of cyclooxygenase-2 induced following traumatic spinal cord injury. (2005)
  • Author(s): ADACHI K, Yimin Yu, SATAKE K, MATSUYAMA Y, ISHIGURO N, SAWADA M, HIRATA Y, KIUCHI K
  • Journal Title: Neuroscience Research 51 Pages: 73-80
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Rabies virus-induced activation of MAPK and NF-kappaB signaling pathways regulates expression of CXC and CC chemokine ligands in microglia (2005)
  • Author(s): NAKAMICHI, K, SAIKI, M, SAWADA, M, YAMAMURO, Y, MORIMOTO, K, KURANE, I
  • Journal Title: Journal of Virology 79 Pages: 11801-11812
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Double-stranded RNA stimulates chemokine expression in microglia through vacuolar pH-dependent activation of intracellular signaling pathways (2005)
  • Author(s): NAKAMICHI, K, SAIKI, M, SAWADA, M, TAKAYAMA-ITO, M, YAMAMURO, Y, MORIMOTO, K, KURANE, I
  • Journal Title: Journal of Neurochemistry 95 Pages: 273-283
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Vitamin K2 ameliorates experimental autoimmune encephalomyelitis in Lewis rats (2005)
  • Author(s): MORIYA, M, NAKATSUJI, Y, OKUNO, T, HAMASAKI, T, SAWADA, M, SAKODA, S
  • Journal Title: Journal of Neuroimmunology 170(1-2) Pages: 11-20
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A lentiviml expression system demonstrates that La protein of Theiler's murine encephalomyelitis virus (TMEV) has an anti-apoptotic effect in a macrophage cell line (2005)
  • Author(s): HIMEDA, T, OHARA, Y, ASAKURA, K, KONTANI, Y, SAWADA, M
  • Journal Title: Microb Pathogenesis 38(5-6) Pages: 201-207
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Peripheral injection of lipopolysaccharide enhances expression of inflammatory cytokins in murine locus coeruleus : possible role of increased norepinephrine turnover (2005)
  • Author(s): KANEKO, Y S, MORI, K, NAKASHIMA, A, SAWADA, M, NAGATSU, I, OTA, A
  • Journal Title: Journal of Neurochemistry 94(2) Pages: 393-340
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Tonic-clonic seizures induce division of neuronal progenitor cells with concomitant changes in expression of neurotrophic factors in the brain of pilocarpine-treated mice (2005)
  • Author(s): HAGIHARA, H, HARA, M, TSUNEKAWA, K, NAKAGAWA, Y, SAWADA, M, NAKANO, K
  • Journal Title: Molecular Brain Research 139(2) Pages: 258-266
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Inhibition of inflammatory cytokine secretion from mouse microglia cells by DHMEQ, an NF-kappaB inhibitor (2005)
  • Author(s): TAKATSUNA, H, MORITA, S, NAGATSU, T, SAWADA, M, UMEZAWA, K
  • Journal Title: Biomedecine & Pharmacotherapy 59(6) Pages: 318-322
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Inflammatory process in Parkinson's disease : role for cytokines (2005)
  • Author(s): NAGATSU, T, SAWADA, M
  • Journal Title: Current Pharmceutical Design 11 Pages: 999-1016
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Cytokine production of activated microglia and decrease in neurotrophic factors of neurons in the hippocampus ofLewy body disease brains (2005)
  • Author(s): IMAMURA, K, HISHIICAWA, N, ONO, K, SUZUKI, H, SAWADA, K, NAGATSU, T, YOSHIDA, M, HASHIZUME, Y
  • Journal Title: Acta Neuropathologica 109 Pages: 141-150
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Amyloid-beta peptides induce cell proliferation and macrophage colony-stimulating factor expression via the PI3-kinase (2005)
  • Author(s): ITO, S, SAWADA, M, HANEDA, M, FUJII, S, OHHASHI, K, KIUCHI, K, TAKAHASHI, M, ISOBE, K
  • Journal Title: Akt pathway in cultured Ra2 microglial cells FEBS Letters 579 Pages: 1995-2000
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A lentiviral expression system demonstrates that L* protein of Thence murine encephalomyelitis virus (TMEV) is essential for virus growth in a murine macrophage-like cell line (2005)
  • Author(s): HIMEDA, T, OHARA, Y, ASAKURA, K, KONTANI, Y, MURAKAMi, M, SUZUKI, H, SAWADA, M
  • Journal Title: Virus Research 108 Pages: 23-28
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Localization of cyclooxygenase-2 induced following traumatic spinal cord injury (2005)
  • Author(s): ADACHI, K, Yimin, Yu, SATAKE, K, MATSUYAMA, Y, ISHIGURO, N, SAWADA, M, HIRATA, Y, KIUCHI, K
  • Journal Title: Neuroscience Research 51 Pages: 73-80
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Superoxide production at phagosomal cup/phagosome through betaI protein kinase C during FcgammaR-mediated phagocytosis in microglia. (2004)
  • Author(s): UEYAMA T., Lennartz M. R., NODA Y, KOBAYAHSI T, SHIRAI Y, RIKITAKE K, YAMASAKI T, HAYASHI S, SAKAI, N, SEGUCHI H, SAWADA M, SUMIMOTO H, SAITO N
  • Journal Title: Journal of Immunology 173(7) Pages: 4582-4589
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Superoxide production at phagosomal cup (2004)
  • Author(s): UEYAMA, T, Lennartz, M. R., NODA, Y, KOBAYASHI, T, SHIRAI, Y, RIKITAKE, K, YAMASAKI, T, HAYASHI, S, SAKAI, N, SEGUCHI, H, SAWADA, M, SUMIMOTO, H, SAITO, N
  • Journal Title: phagosome 173(7) Pages: 4582-4589
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Expression of Cytokines and Neurotrophins after acute Subarachnoid Hemorrhage. (2008)
  • Author(s): Fatima A. S, Rowena F, ONO K, SUZUKI H, SAWADA M, KANZAWA T
  • Organizer: 2008 International Stroke Conference
  • Place of Presentation: New Orleans, America
  • Year and Date: 2008-02-21
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Expression of Cytokines and Neurotrophins after acute Subarachnoid Hemorrhage (2008)
  • Author(s): Fatima, A.S, Rowena, F, ONO, K, SUZUKI, H, SAWADA, M, KANZAWA, T
  • Organizer: 2008 International Stroke Conference
  • Place of Presentation: New Orleans, America
  • Year and Date: 2008-02-21
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 脳損傷モデルマウスにおける脳移行性骨髄細胞の活性化と分化に関する解析 (2007)
  • Author(s): 小野健治、山本奈穂、鈴木弘美、佐藤愛美、神澤孝夫、澤田 誠
  • Organizer: 第30回日本分子生物学会年会、第80回日本生化学会大会合同大会
  • Place of Presentation: 横浜
  • Year and Date: 20071211-15
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Activation and differentiation of brain-migrated immature bone marrow cells in an artificial brain injury (2007)
  • Author(s): ONO, K, YAMAMOTO, N, SUZUKI, H, SATO, E, KANZAWA, T, SAWADA, M
  • Organizer: Biochemistry and Molecular Biology 2007
  • Place of Presentation: Yokohama
  • Year and Date: 20071211-15
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 血液脳関門を壊さない脳標的化ドラッグデリバリー (2007)
  • Author(s): 澤田 誠
  • Organizer: 群馬大学生体調節研究所シンポジウム
  • Place of Presentation: 前橋市、群馬県
  • Year and Date: 20071129-30
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Brain-targeted drug delivery system without break of blood- brain barrier (2007)
  • Author(s): SAWADA, M
  • Organizer: Symposium of Institute for Molecular and Cellular Regulation, Gunma University
  • Place of Presentation: Maebashi
  • Year and Date: 20071129-30
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Neuroprotective and toxic change of microglia in neurodegenerative disease (2007)
  • Author(s): SAWADA M
  • Organizer: 3rd International Symposium on Dopaminergic and Nondopaminergic Mechanisms in Parkinson's Disease(INPD)
  • Place of Presentation: 大阪
  • Year and Date: 20071123-24
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 脳損傷モデルマウスにおける脳移行性骨髄細胞と分化のイメージング (2007)
  • Author(s): 小野健治、山本奈穂、鈴木弘美、神澤孝夫、澤田 誠
  • Organizer: 第50回日本神経化学(横浜)大会、第30回日本神経科学大会、第17回日本神経回路学会大会合同大会
  • Place of Presentation: 横浜
  • Year and Date: 20070910-12
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] In viva imaging indicates activation and differentiation of of brain-migrated immature bone marrow cells in an artificial injury. (2007)
  • Author(s): ONO, K, YAMAMOTO, N, SUZUKI, H, KANZAWA, T, SAWADA, M
  • Organizer: Neuro 2007
  • Place of Presentation: Yokohama
  • Year and Date: 20070910-12
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 動物PETによるラット線条体障害モデルにおけるミクログリア毒性転換の検討 (2007)
  • Author(s): 伊藤文隆、工藤 元、外山 宏、鈴木弘美、籏野健太郎、加藤隆司、片田和広、市瀬正則、澤田 誠、伊藤健吾
  • Organizer: 日本分子イメージング学会第2回総会・学術集会
  • Place of Presentation: 福井
  • Year and Date: 20070628-29
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Evaluation of toxic con-version of microglia on rat striatum injury model using animal PET (2007)
  • Author(s): ITO, F, KUDO, G, TOYAMA, H, SUZUKI, H, HATANO, K, KATO, T, KATADA, K, ICHISE, M, SAWADA, M, ITO, K
  • Organizer: 2nd Japanese Society for Molecular Imaging
  • Place of Presentation: Fukui
  • Year and Date: 20070628-29
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Neuroprotective and toxic change of microglia in neurodegenerative disease (2007)
  • Author(s): SAWADA, M
  • Organizer: 3rd International Symposium on Dopaminergic and Nondopaminergic Mechanisms in Parkinson's Disease (INPD) 2007
  • Place of Presentation: Osaka
  • Year and Date: 2007-11-24
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 動物PETによるラット線条体障害モデルにおけるミクログリアの毒性転換の検討 (2007)
  • Author(s): 鈴木弘美、外山 宏、籏野健太郎、工藤 元、伊藤文隆、小野健治、加藤隆司、伊藤健吾、澤田 誠
  • Organizer: 第16回日本バイオイメージング学会学術集会
  • Place of Presentation: 野田、千葉県
  • Year and Date: 2007-10-31
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Evaluation of toxic conversion of microglia on rat striatum injury model using animal PET (2007)
  • Author(s): SUZUKI, H, TOYAMA, H, HATANO, K, KUDO, G, ITO, F, ONO, K, KATO, T, ITO, K, SAWADA, M
  • Organizer: 16th Annual Meeting ofBioimaging Society 2007
  • Place of Presentation: Noda city, Chiba Pref
  • Year and Date: 2007-10-31
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] microgliaの起源,疾患との関連 (2007)
  • Author(s): 澤田 誠
  • Organizer: 第112回目本解剖学会総会・全国学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2007-03-27
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Origin of microglia and their related disorders (2007)
  • Author(s): SAWADA, M
  • Organizer: The 112th Annual Meeting of Japanese Association of Anatomies
  • Place of Presentation: Osaka
  • Year and Date: 2007-03-27
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] ミクログリアイメージングの意義 (2006)
  • Author(s): 澤田 誠
  • Organizer: 第18回日本脳循環代謝学会総会
  • Place of Presentation: 東京
  • Year and Date: 20061110-11
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Significance of microglia imaging (2006)
  • Author(s): SAWADA, M
  • Organizer: The 18th Annual Meeting of the Japanese Society of Cerebral Blood Flow and Metabolism
  • Place of Presentation: Tokyo
  • Year and Date: 20061110-11
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Imaging of activated microglia in brain injury (2006)
  • Author(s): 鈴木弘美, 外山 宏, 旗野健太郎, 工藤 元, 伊藤文隆, 小野健治, 加藤孝司, 伊藤健吾、澤田 誠
  • Organizer: 第49回神経化学会大会
  • Place of Presentation: 名古屋
  • Year and Date: 20060914-16
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Control of microglia neurotoxicity via β-adrenergic receptors (2006)
  • Author(s): 小野健治, 佐藤愛美, 澤田 誠
  • Organizer: 第49回神経化学会大会
  • Place of Presentation: 名古屋
  • Year and Date: 20060914-16
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Imaging of activated microglia in brain injury (2006)
  • Author(s): SUZUKI, H, TOYAMA, H, HATANO, K, KUDO, G, ITO, F, ONO, K, KATO, K, ITO, K, SAWADA, M
  • Organizer: The 49th Annual Meeting of the Japanese Society for Neurochemistry
  • Place of Presentation: Nagoya
  • Year and Date: 20060914-16
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Control of microglia neurotoxicity via - adrenergic receptors (2006)
  • Author(s): ONO, K, SATO, E, SAWADA, M
  • Organizer: The 49th Annual Meeting of the Japanese Society for Neurochemistry
  • Place of Presentation: Nagoya
  • Year and Date: 20060914-16
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 乳酸アシド・シス環境におけるマイクログリアのプロトンチャネル活性化 (2006)
  • Author(s): 久野みゆき, 森畑宏一, 川脇順子, 翁 昌子, 澤田 誠, 酒井 啓
  • Organizer: 第29回日本神経科学大会
  • Place of Presentation: 京都
  • Year and Date: 20060719-21
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] ミクログリアの活性化がMPTP投与による黒質線条体ドーパミン神経細胞に及ぼす影響は新生児マウスと老齢マウスとは異なる (2006)
  • Author(s): 澤田浩秀, 菱田良平, 平田洋子, 小野健治, 鈴木弘美, 村松慎一, 中野今治, 土田邦博, 永津俊治, 澤田 誠
  • Organizer: 第29回日本神経科学大会
  • Place of Presentation: 京都
  • Year and Date: 20060719-21
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] よいミクログリアと悪いミクログリア (2006)
  • Author(s): 澤田 誠
  • Organizer: 第29回日本神経科学大会
  • Place of Presentation: 京都
  • Year and Date: 20060719-21
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Activation of voltage-gated proton channels during lactic acidosis in microglia, pH-sensing cells in the CNS (2006)
  • Author(s): KUNO, M, MORIHATA, K, KAWAWAKI, J, OKINA, M, SAWADA, M, SAKA, H
  • Organizer: The 29th Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: Kyoto
  • Year and Date: 20060719-21
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Activated microglia affect the nigro-striatal dopamine neurons differently in neonatal and aged mice treated with MPTP (2006)
  • Author(s): SAWADA, H, HISHIDA, R, HIRATA, Y, ONO, K, SUZUKI, H, MURAMATSU, S, NAKANO, I, TSUCHIDA, K, NAGATSU, T, SAWADA, M
  • Organizer: The 29th Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: Kyoto
  • Year and Date: 20060719-21
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Good or bad-microglia in the brain diseases (2006)
  • Author(s): SAWADA, M
  • Organizer: The 29th Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: Kyoto
  • Year and Date: 20060719-21
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Clearance of Polysialic acid during LPS-induced activation on microglia cells (2006)
  • Author(s): SATO C, YABE U, SAWADA M, KITAJIMA K
  • Organizer: 20th IUBMB Inter-national Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
  • Place of Presentation: 東京
  • Year and Date: 20060618-23
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Activated microglia affect the nigro-striatal dopamine neurons differently in neonatal and aged mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahy dropyridine (2006)
  • Author(s): SAWADA H, HISHIDA R, HIRATA Y, ONO K, SUZUKI H, MURAMATSU S, NAKANO I, TSUCHIDA K, NAGATSU T, SAWADA M
  • Organizer: 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
  • Place of Presentation: 東京
  • Year and Date: 20060618-23
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Clearance of Polysialic acid during LPS-induced activation on microglia cells (2006)
  • Author(s): SATO, C, YABE, U, SAWADA, M, KITAJIMA, K
  • Organizer: 20th IUBMB International Congress of Biochemistry and Molecular Biology and Ilth FAOBMB Congress
  • Place of Presentation: Tokyo
  • Year and Date: 20060618-23
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Activated microglia affect the nigro-striatal dopamine neurons differently in neonatal and aged mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (2006)
  • Author(s): SAWADA, H, HISHIDA, R, HIRATA, Y, ONO, K, SUZUKI, H, MURAMATSU, S, NAKANO, I, TSUCHIDA, K, NAGATSU, T, SAWADA, M
  • Organizer: 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11t FAOBMB Congress
  • Place of Presentation: Tokyo
  • Year and Date: 20060618-23
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 1.5T MRIによる定位的ラット脳線条体撮像-定位脳固定具を用いない撮像法の開発 (2006)
  • Author(s): 伊藤文隆, 工藤 元, 外山 宏, 鈴木弘美, 旗野健太郎, 中根正人, 大橋正夫, 加藤隆司, 片田和広, 市瀬正則, 澤田 誠, 伊藤健吾
  • Organizer: 日本分子イメージング学会設立総会及び第1回学術集会
  • Place of Presentation: 京都
  • Year and Date: 20060523-24
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Stereotaxic imaging of the rat brain Striatum using 1.5T Mill system -Develop-ment of reproducible imaging technique without stereotaxic device (2006)
  • Author(s): ITO, F, KUDO, G, TOYAMA, H, SUZUKI, H, HATANO, K, NAKANE, M, OHASHI, M, KATO, T, KATADA, K, ICHISE, M, SAWADA, M ITO, K
  • Organizer: 1st Annual Meeting of Japanese Society for Molecular Imaging
  • Place of Presentation: Kyoto
  • Year and Date: 20060523-24
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 血液脳関門を壊さない脳標的化ドラッグデリバリー (2006)
  • Author(s): 澤田 誠
  • Organizer: 第18回神経免疫学会 モーニングレクチャー.
  • Place of Presentation: 名古屋
  • Year and Date: 2006-03-02
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Brain-targeted drug delivery system without break of blood-brain barrier (2006)
  • Author(s): SAWADA, M
  • Organizer: The 18th Annual Meeting of Japanese Society for Neuroimmunology
  • Place of Presentation: Nagoya
  • Year and Date: 2006-03-02
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 末梢性ベンゾジアゼピン受容体製剤11C-CB148と11C-PK11195の比較-動物PETによる検討- (2005)
  • Author(s): 関亦克彦, 籏野健太郎, 外山 宏, 鈴木弘美, 加藤隆司, 片田和廣, 澤田 誠, 伊藤健吾
  • Organizer: 第45回日本核医学会総会
  • Place of Presentation: 東京
  • Year and Date: 20051111-13
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Comparison of 11C-CB148 and11C-PK11195, ligands for peripheral benzodiazepine receptors, by PET (2005)
  • Author(s): SEKIMATA, K, HATANO, K, TOYAMA, H, SUZUKI, H, KATO, T, KATADA, K, SAWADA, M, ITO, K
  • Organizer: The 45th of Annual Meeting of Japanese Nuclear Medicine
  • Place of Presentation: Tokyo
  • Year and Date: 20051111-13
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] HIV-Nefを導入したミクログリア細胞による神経細胞機能障害 (2005)
  • Author(s): 澤田 誠, 三井健一, 鈴木弘美, 小野健治, Karl-Heinz Krause, 鈴木和男
  • Organizer: 第16回日本生体防御学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 20050804-06
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Neuronal damage by microglia transduced with HIV-Nef (2005)
  • Author(s): SAWADA, M, MITSUI, K, SUZUKI, H, ONO, K, KRAUSE, K, SUZUKI, K
  • Organizer: 16th Japanese Society for Bio-Defence
  • Place of Presentation: Tokyo
  • Year and Date: 20050804-06
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 末梢性ベンゾジアゼピン受容体製剤11C-CB148と11C-PK11195の比較-動物PETによる検討- (2005)
  • Author(s): 工藤元, 関亦克彦, 籏野健太郎、外山宏, 鈴木弘美, 加藤隆司, 片田和廣, 澤田 誠, 伊藤健吾
  • Organizer: 核医学会中部地方会
  • Place of Presentation: 富山
  • Year and Date: 20050702-03
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Comparison of I IC-CB148 and 11C-PK11195, ligands for peripheral benzodiazepine receptors, by PET (2005)
  • Author(s): KUDO, G, SEKIMATA, K, HATANO, K, TOYAMA, H, SUZUKI, H, KATO, T, KATADA, K, SAWADA, M, ITO, K
  • Organizer: Local Meeting of Society for Nuclear Medicine Chubu Branch
  • Place of Presentation: Toyama
  • Year and Date: 20050702-03
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 脳特異的な薬物・遺伝子・タンパク質導入技術の開発 (2005)
  • Author(s): 澤田 誠
  • Organizer: 環境医学研究所国際シンポジウム
  • Place of Presentation: 名古屋
  • Year and Date: 2005-11-30
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Brain-specific Delivery and Possible Therapeutic Approach based on Microglia (2005)
  • Author(s): SAWADA, M
  • Organizer: International Symposium for Environ-mental Medicine
  • Place of Presentation: Nagoya
  • Year and Date: 2005-11-30
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 活性型ミクログリアのIn Vivoイメージング (2005)
  • Author(s): 鈴木弘美, 外山 宏, 工藤 元, 籏野健太郎, 関亦克彦, 小野健治, 中根正人, 加藤隆司, 伊藤健吾, 澤田 誠
  • Organizer: 第14回日本バイオイメージング学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2005-10-27
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] In vivo imaging of brain damages based on microglial activation (2005)
  • Author(s): SUZUKI, H, TOYAMA, H, KUDO, G, HATANO, K, ONO, K, SHEKIMATA, K, NAKANE, M, KATO, T, ITO, K, SAWADA, M
  • Organizer: 14th Annual Meeting of Bioimaging Society
  • Place of Presentation: Tokyo
  • Year and Date: 2005-10-27
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 人に優しい脳疾患治療法開発の試み アルツハイマー病-その病態と克服へ向けた試み (2005)
  • Author(s): 澤田 誠
  • Organizer: 平成17年度市民公開講座
  • Place of Presentation: 名古屋
  • Year and Date: 2005-08-21
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Development of less-invasive treatment systems for brain diseases ; Our efforts for diagnosis and treatment of Alzheimer's disease (2005)
  • Author(s): SAWADA, M
  • Organizer: The Open seminar of RIEM 2005
  • Place of Presentation: Nagoya
  • Year and Date: 2005-08-21
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 活性型ミクログリアのIn Vivoイメージング (2005)
  • Author(s): 鈴木弘美, 外山宏, 工藤元, 旗野健太郎, 関亦克彦, 小野健治, 加藤隆司, 伊藤健吾, 澤田 誠
  • Organizer: 第9回ニューロイメージングカンファランス
  • Place of Presentation: 名古屋
  • Year and Date: 2005-02-05
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] In vivo imaging of brain damages based on microglial activation (2005)
  • Author(s): SUZUKI, H, TOYAMA, H, KUDO, O, HATANO, K, SEKIMATA, K, ONO, K, KATO, T, ITO, K, SAWADA, M
  • Organizer: 9th Neuroimaging Conference
  • Place of Presentation: Nagoya
  • Year and Date: 2005-02-05
  • Description: 「研究成果報告書概要(欧文)」より
• [Book] 老年期痴呆研究会誌 (2007)
  • Author(s): 澤田 誠
  • Total Pages: 14:59
  • Publisher: 老年期痴呆研究会誌
  • Description: 「研究成果報告書概要(和文)」より
• [Book] けいれん発作とグリア細胞の動態 (2005)
  • Author(s): 萩原英雄, 澤田 誠
  • Total Pages: 23(2)
  • Publisher: CLINICAL NEUROSCIENCE別冊 中外医学社
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 血液脳関門とDDS. (2005)
  • Author(s): 澤田 誠
  • Total Pages: 214(9)
  • Publisher: 医学のあゆみ
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] 多価結合手を有し代謝安定性が向上した脳移行性ポリペプチド (2007)
  • Inventor(s): 中條智洋、原啓高、山本一匡、鈴木弘美、澤田誠、須原哲也、樋口真人、原田平輝志、季斌
  • Industrial Property Rights Holder: (株)ティッシュターゲッティングジャパン放射線医学総合研究所
  • Industrial Property Number: 特願2007-054260
  • Filing Date: 2007-03-05
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] 脳移行性細胞、およびその利用 (2005)
  • Inventor(s): 澤田誠、向山博幸
  • Industrial Property Rights Holder: (株)ティッシュターゲッティングジャパン
  • Industrial Property Number: 特願2005-246256PCT/JP2006/316673
  • Filing Date: 2005-08-25
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] 脳移行性骨髄前駆細胞 (2004)
  • Inventor(s): 澤田誠、小野健治
  • Industrial Property Rights Holder: (株)ティッシュターゲッティングジャパン
  • Industrial Property Number: 特願2004-298170PCT/JP2005/018785
  • Filing Date: 2004-10-12
  • Description: 「研究成果報告書概要(和文)」より