2005 Fiscal Year Final Research Report Summary
Development of new medical gel materials using synthetic carbohydrate polymer
| Project/Area Number |
16300146
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | HOKKAIDO UNIVERSITY |
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Principal Investigator |
KAKUCHI Toyoji Hokkaido Univ., Graduate School of Engineering, Prof., 大学院・工学研究科, 教授 (80113538)
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| Co-Investigator(Kenkyū-buntansha) |
SATOH Toshifumi Hokkaido Univ., Graduate School of Engineering, Instructor, 大学院・工学研究科, 助手 (80291235)
KAGA Harumi National Institute of Advanced Industrial Science and Technology (AIST), Chief scientist, 産業技術総合研究所・ゲノムファクトリー研究部門, 主任研究員 (20356752)
YANO Shigenobu Nara women Univ., Graduate School of Humanities and Sciences, Prof., 大学院・人間文化研究科, 教授 (60011186)
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| Project Period (FY) |
2004 – 2005
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| Keywords | Cellulose / Hyperbranched Carbohydrate Polymer / Gel / Hemostat / Sealant / Polycarbohydrate Derivative |
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| Research Abstract |
Gel-materials, such as gelatin, collagen, and fibrinogen, derived from animals and humans, have been used widely in medical applications, although the materials include the possibilities of the contagions of a virus and an allergic material. We recently discovered that a novel carbohydrate polymer having a specific structure formed a new class of gel-material. Depending on the formulation and preparation method, materials ranging from viscous liquids, soft gels, and tough films can be obtained with widely varying gel formation kinetics. Since the starting materials are classified as biocompatible and biodegradable, this new class of gels has many potential medical applications, such as hemostatic, adhesive, and coating agents. Carbohydrate polymers having a specific structure can be synthesized from naturally occurring sugars or compounds microwave-decomposed from polysaccharide. The novel carbohydrate polymers have characteristics as follows ; 1)basic materials for medical applications at a reasonable cost, 2)easy control of the chemical and physical properties, 3)biocompatible and biodegradable materials. The reaction of the carbohydrate polymer with a gelling agent immediately forms the gel-materials, which offers several advantages over conventional gel preparations, including the use of non-contagion materials and short preparation times. The gel-materials are a versatile new class of biomaterials that hold promise for a wide variety of medical applications.
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Research Products
(28 results)
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[Journal Article] Synthesis of Unimolecular Reversed Micelle consisting of Poly-L-lactide Shell and Hyperbranched D-mannan core2006
Author(s)
Satoh, T., Tamaki, M., Kitajyo, Y., Maeda, T., Ishihara, H., Imai, T., Kaga, H., Kakuchi, T
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Journal Title
J.Polym.Sci., Part A : Polym.Chem. 44(1)
Pages: 406-413
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Synthesis and Photocrosslinking Reaction of N-Allylcarbamoylmethyl Cellulose Leading to Hydrogel2006
Author(s)
Shen, X., Kitajyo, Y., Duan, Q., Narumi, A., Kaga, H., Kaneko, N., Satoh, T., Kakuchi, T.
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Journal Title
Polym.Bull. 56(2-3)
Pages: 137-143
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Synthesis of Hyperbranched Polytetritol by Ring-Opening Multibranching Polymerizations of 2,3-Anhydroerythritol and 2,3-Anhydro-DL-threitol2005
Author(s)
Imai, T., Nawa, Y., Kitajyo, Y., Satoh, T., Kaga, H., Kaneko, N., Kakuchi, T.
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Journal Title
Macromolecules 38(5)
Pages: 1648-1654
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Synthesis, Branched Structure, and Solution Property of Hyperbranched D-Glucan and D-Galactan2005
Author(s)
Satoh, T., Imai, T., Ishihara, H., Maeda, T., Kitajyo, Y., Sakai, Y., Kaga, H., Kaneko, N., Ishii, F., Kakuchi, T.
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Journal Title
Macromolecules 38(10)
Pages: 4202-4210
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Synthesis and Characterization of Cellulose Carbamates Having α-Amino Acid Moieties2005
Author(s)
Shen, X., Sugie, N., Duan, Q., Kitajyo, Y., Satoh, T., Kakuchi, T.
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Journal Title
Polym.Bull. 55(5)
Pages: 317-322
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Novel Synthetic Method for Preparing Artificial Carbohydrate Polymers2005
Author(s)
Satoh, T., Imai, T., Kitajyo, Y., Kakuchi, T.
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Journal Title
Current Topics in Polymer Research (ed.Bregg, R.K.)(Nova Science Publishers, Inc., Hauppauge, NY, USA)
Pages: 195-232
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Synthesis of Hyperbranched Polysaccharide by Thermally Induced Cationic Polymerization of 1,6-Anhydrohexopyranose2004
Author(s)
Satoh, T., Imai, T., Kitajyo, Y., Maeda, T., Narumi, A., Kaga, H., Kaneko, N., Kakuchi, T.
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Journal Title
Macromol.Symp. 217(1)
Pages: 39-46
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Synthesis of Hyperbranched Carbohydrate Polymer by Ring-Opening Multibranching Polymerization of 1,4-Anhydroerythritol and 1,4-Anhydro-L-threitol2004
Author(s)
Imai, T., Satoh, T., Kaga, H., Kaneko, N., Kakuchi, T.
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Journal Title
Macromolecules 37(9)
Pages: 3113-3119
Description
「研究成果報告書概要(欧文)」より
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