2005 Fiscal Year Final Research Report Summary
Exploration of functional non-coding sequences in the higher eukaryotic genomes.
| Project/Area Number |
16310142
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied genomics
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| Research Institution | National Institute of Advanced Industrial Science and Technology |
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Principal Investigator |
IMANISHI Tadashi National Institute of Advanced Industrial Science and Technology, Biological Information Research Center, Team Leader, 生物情報解析研究センター, 研究チーム長 (80270461)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAGUCHI Yumi National Institute of Advanced Industrial Science and Technology, Researcher, 研究員 (10358236)
ITOH Takeshi National Institute of Advanced Industrial Science and Technology, Genome Research Department, Team Leader, ゲノム研究グループ, チームリーダー (80356469)
IKEO Kazuho National Institute of Genetics Center for Information Biology and DNA Data Bank of Japan, Associate Professor, 生命情報DDBJ研究センター, 助教授 (20249949)
BARRERO Roberto National Institute of Genetics Center for Information Biology and DNA Data Bank of Japan, Assistant Professor, 生命情報DDBJ研究センター, 助手 (20390627)
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| Project Period (FY) |
2004 – 2005
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| Keywords | sequence motif / human genome / microRNA / comparative genomics |
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| Research Abstract |
In order to explore functional non-coding sequences hidden in the higher eukaryotic genomes, we conducted bioinformatic analyses of whole genomic sequences of human and other major model animals. First, we conducted comparative genomics analyses of human and other mammalian species, and created a new database of genomic sequence alignments named as G-compass (http://www.jbirc.aist.go.jp/g-compass/). While creating the genomic alignments, we discovered 82 human genomic regions that were completely conserved between human and mouse. Some of these conserved regions overlapped with known genes, but others were suggested to contain unidentified functional elements in the human genome. These results were reported in a paper by Fujii et al. (2005). Furthermore, we compared whole genomic sequences of human, chimpanzee, mouse and rat, and found that only 16.4% of the human genome is conserved in all these four species. This result was reported in a paper by Sakate et al. (2006). Next, we explored functional non-coding elements in the human genome. By sequence analyses of human genome and human transcripts, we predicted many new candidates of human microRNAs and their potential target (regulated) genes. A part of these results was applied for patents. In conclusion, we developed methods for identifying functional non-coding elements in the genomes, and succeeded in identifying some of them.
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Research Products
(16 results)
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[Journal Article] Molecular characterization of the developmental gene in eyes : through data-mining on integrated transcriptome databases. Clin Biochem. 2006 Mar;39(3) : 224-30. Epub 2006 Jan 19.2006
Author(s)
Choy KW, Wang CC, Ogura A, Lau TK, Rogers MS, Ikeo K, Gojobori T, Tang LY, Lam DS, Chung TK, Pang CP
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Journal Title
Clin Biochem 39(3)
Pages: 224-230
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Molecular characterization of the developmental gene in eyes : through data-mining on integratedtranscriptome databases.2006
Author(s)
Choy KW, Wang CC, Ogura A, Lau TK, Rogers MS, Ikeo K, Gojobori T, Tang LY, Lam DS, Chung TK, Pang CP
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Journal Title
Clin Biochem. 39(3)
Pages: 224-30
Description
「研究成果報告書概要(欧文)」より
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