Identifications of small molecule drug-binding proteins by using the affinities

2006 Fiscal Year Final Research Report Summary

• Project/Area Number: 16310155
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Living organism molecular science
• Research Institution: Tokyo University of Science
• Principal Investigator: SUGAWARA Fumio Tokyo University of Science, Department of Applied Biological Science, Professor, 理工学部, 教授 (30192123)
• Project Period (FY): 2004 – 2006
• Keywords: anti-cancer drug / camptothecin / etoposide / phage display / binding protein / receptor / SPR / QCM

Research Abstract

This research subject aimed to develop new and facile methods to identify drug targeted binding proteins.
In 2004 and 2005, we studied on two anti-cancer drugs, camptothecin and etoposide as ligand to identify the binding proteins as receptors. The affinities between drug small molecules and binding proteins have been applied for our phase display screenings, which will give us high affinity phage particles displaying drug binding proteins and/or peptides. Based on the cDNA sequence data composed of the selected phages, the homology search with BLAST or FASTA program informed us that camptothecin receptor can be a prostaglandin receptor EP1 and etoposide receptor can be a transcription factor E2F. We established those bindings by SPR (surface plasmon resonance) and/or QCM (quartz crystal micro balance).
In 2006, we improved two methods. First, we employed PEG (polyethylene glycerol) beads for organic synthesis to avoid non-specific bindings between drug and proteins. Second, we immobilized ligand on a gold QCM sensor chip to afford "self-assembled membrane". In either case, we successfully identified FKBP12 as a receptor of SLF as a ligand.
Overall, we have successfully identified new target molecules of anti-cancer drugs with our improved methods. It can be expected to identify both binding proteins and receptors for drugs and other biological important small molecules.

Research Products

• [Journal Article] Anti-tumor effects of dehydroaltenusin, a specific inhibitor of mammalian DNA polymerase alpha (2007)
  • Author(s): Maeda N, Kokai Y, Ohtani S, Sahara H, Kuriyama I, Kamisuki S, Takahashi S, Sakaguchi K, Sugawara F, Yoshida H, Sato N, Mizushina Y
  • Journal Title: Biochem Biophys Res Commun. 352 Pages: 390-396
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Inhibitory action of polyunsaturated fatty acids on IMP dehydrogenase. (2007)
  • Author(s): Mizushina Y, Dairaku I, Yanaka N, Takeuchi T, Ishimaru C, Sugawara F, Yoshida H, Kato N
  • Journal Title: Biochimie 89(5) Pages: 581-590
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Nodulisporol and Nodulisporone, novel specific inhibitors of human DNA polymerase lambda from a fungus, Nodulisporium sp (2007)
  • Author(s): Kamisuki S, Ishimaru C, Onoda K, Kuriyama I, Ida N, Sugawara F, Yoshida H, Mizushina Y
  • Journal Title: Bioorg Med Chem 15(9) Pages: 3109-3114
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Sulfoglycolipids as candidate antiangiogenic radiosensitizers. Miura M, Sakimoto I, Ohta K, Sugawara F, Sakaguchi K. (2007)
  • Author(s): Miura M, Sakimoto I, Ohta K, Sugawara F, Sakaguchi K
  • Journal Title: Anticancer Drugs 18(1) Pages: 1-5
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Structure-activity relationship of a glycolipid, sulfoquinovosyl diacylglycerol, with the DNA binding activity of p53 (2007)
  • Author(s): Iijima H, Kasai N, Chiku H, Takeuchi T, Kuramochi K, Hanashima S, Kobayashi S, Sugawara F, Sakaguchi K, Yoshida H, Mizushina Y
  • Journal Title: Int J Mol Med 19(1) Pages: 41-48
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Inhibitory effect of sulfoquinovosyl diacylglycerol on prokaryotic polymerase I activity and cell growth of Escherichia coli. (2007)
  • Author(s): Furukawa T, Nishida M, Hada T, Kuramochi K, Sugawara F, Kobayashi S, Iijima H, Shimada H, Yoshida H, Mizushina Y
  • Journal Title: J Oleo Sci. 6(1) Pages: 43-47
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Anti-tumor effects of dehydroaltenusin, a specific inhibitor of mammalian DNA polymerase alpha. (2007)
  • Author(s): Maeda N, Kokai Y, Ohtani S, Sahara H, Kuriyama I, Kamisuki S, Takahashi S, Sakaguchi K, Sugawara F, Yoshida H, Sato N, Mizushina Y.
  • Journal Title: Biochem Biophys Res Commun. 352 Pages: 390-6
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Inhibitory action of polyunsaturated fatty acids on IMP dehydrogenase. (2007)
  • Author(s): Mizushina Y, Dairaku I, Yanaka N, Takeuchi T, Ishimaru C, Sugawara F, Yoshida H, Kato N.
  • Journal Title: Biochimie. 89(5) Pages: 581-90
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Nodulisporol and Nodulisporone, novel specific inhibitors of human DNA polymerase lambda from a fungus, Nodulisporium sp. (2007)
  • Author(s): Kamisuki S, Ishimaru C, Onoda K, Kuriyama I, Ida N, Sugawara F, Yoshida H, Mizushina Y.
  • Journal Title: Bioorg Med Chem. 15(9) Pages: 3109-14
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Sulfoglycolipids as candidate antiangiogenic radiosensitizers. (2007)
  • Author(s): Miura M, Sakimoto I, Ohta K, Sugawara F, Sakaguchi K.
  • Journal Title: Anticancer Drugs. 18(1) Pages: 1-5
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Structure-activity relationship of a glycolipid, sulfoquinovosyl diacylglycerol, with the DNA binding activity of p53. (2007)
  • Author(s): Iijima H, Kasai N, Chiku H, Takeuchi T, Kuramochi K, Hanashima S, Kobayashi S, Sugawara F, Sakaguchi K, Yoshida H, Mizushina Y.
  • Journal Title: Int J Mol Med. 19(1) Pages: 41-8
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Inhibitory effect of sulfoquinovosyl diacylglycerol on prokaryotic polymerase I activity and cell growth of Escherichia coli. (2007)
  • Author(s): Furukawa T, Nishida M, Hada T, Kuramochi K, Sugawara F, Kobayashi S, Iijima H, Shimada H, Yoshida H, Mizushina Y.
  • Journal Title: J Oleo Sci. 6(1) Pages: 43-7
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Synthesis and absolute configuration of (+)-pseudodeflectusin : structural revision of aspergione B. (2006)
  • Author(s): Saito F, Kuramochi K, Nakazaki A, Mizushina Y, Sugawara F, Kobayashi S
  • Journal Title: Euro J Org Chem. 21 Pages: 4796-4799
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] An emulsion of sulfoquinovosylacylglycerol with long-chain alkanes increases its permeability to tumor cells. (2006)
  • Author(s): Aoki S, Ohta K, Matsumoto K, Sakai H, Abe M, Miura M, Sugawara F, Sakaguchi K
  • Journal Title: J Membr Biol. 213 Pages: 11-18
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Characterization of a second proliferating cell nuclear antigen (PCNA2) from Drosophila melanogaster. (2006)
  • Author(s): Ruike T, Takeuchi R, Takata K, Oshige M, Kasai N, Shimanouchi K, Kanai Y, Nakamura R, Sugawara F, Sakaguchi K
  • Journal Title: FEBS J. 273 Pages: 5062-5073
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Synthesis of plakevulin A and structure-activity relationships of its related compounds against DNA polymerases. (2006)
  • Author(s): Kuramochi K, Saito F, Takeuchi R, Era T, Takemura M, Kobayashi J, Sakaguchi K, Kobayashi S, Sugawara F
  • Journal Title: Tertrahedron 62 Pages: 8006-8015
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Total synthesis and stereochemistry of the antitumor antibiotics PD 113,271 (2006)
  • Author(s): Takeuchi T, Kuramochi K, Kobayashi S, Sugawara F
  • Journal Title: Org Lett. 8 Pages: 5307-5310
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Identification of Antibiotic Clarithromycin Binding Peptide Displayed by T7 Phage Particles. (2006)
  • Author(s): Morimura T, Noda N, Kato Y, Watanabe T, Saitoh T, Yamazaki T, Takata K, Aoki S, Ohta K, Ohshige M, Sakaguchi K, Sugawara F
  • Journal Title: J Antibiot. 59 Pages: 625-632
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Site-directed mutational analysis of structural interactions of low molecule compounds binding to the N-terminal 8kDa domain of DNA polymerase beta. (2006)
  • Author(s): Murakami S, Kamisuki S, Takata K, Kasai N, Kimura S, Mizushina Y, Ohta K, Sugawara F, Sakaguchi K
  • Journal Title: Biochem Biophys Res Commun. 350 Pages: 7-16
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] The inhibitory action of long-chain fatty acids on the DNA binding activity of p53. (2006)
  • Author(s): Iijima H, Kasai N, Chiku H, Murakami S, Sugawara F, Sakaguchi K, Yoshida H, Mizushina Y
  • Journal Title: Lipids. 41 Pages: 521-527
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Structural relationship of curcumin derivatives binding to the BRCT domain of human DNA polymerase lambda. (2006)
  • Author(s): Takeuchi T, Ishidoh T, Iijima H, Kuriyama I, Shimazaki N, Koiwai O, Kuramochi K, Kobayashi S, Sugawara F, Sakaguchi K, Yoshida H, Mizushina Y
  • Journal Title: Genes Cells. 11 Pages: 223-235
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Total synthesis of (-)-neoechinulin A (2006)
  • Author(s): Aoki T, Kamisuki S, Kimoto M, Ohnishi K, Takakusagi Y, Kuracmohi K, Takeda Y, Nakazaki A, Kuroiwa K, Ohuchi T, Sugawara F, Arai T, Kobayashi S
  • Journal Title: Synlett. 2006 Pages: 677-680
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Alpha-sulfoquinovosylmonoacylglycerol is a novel potent radiosensitizer targeting tumor angiogenesis. (2006)
  • Author(s): Sakimoto I, Ohta K, Yamazaki T, Ohtani S, Sahara H, Sugawara F, Sakaguchi K, Miura M
  • Journal Title: Cancer Res. 15 Pages: 2287-2295
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Structural relationship of curcumin derivatives binding to the BRCT domain of human DNA polymerase lambda (2006)
  • Author(s): Takeuchi T, Ishidoh T, Iijima H, Kuriyama I, Shimazaki N, Koiwai O, Kuramochi K, Kobayashi S, Sugawara F, Sakaguchi K, Yoshida H, Mizushina Y
  • Journal Title: Genes Cells. 11 Pages: 223-235
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] A high-throughput phage display screening method using a combination of real-time PCR and affinity chromatography. (2006)
  • Author(s): Morohashi K, Arai T, Saito S, Watanabe M, Sakaguchi K, Sugawara F
  • Journal Title: Comb Chem High Throughput Screen. 9 Pages: 55-61
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 5-(Hydroxymethyl)-2-furfural : a selective inhibitor of DNA polymerase lambda and terminal deoxynucleotidyltransferase. (2006)
  • Author(s): Mizushina Y, Yagita E, Kuramochi K, Kuriyama I, Shimazaki N, Koiwai O, Uchiyama Y, Yomezawa Y, Sugawara F, Kobayashi S, Sakaguchi K, Yoshida H
  • Journal Title: Arch Biochem Biophys. 446 Pages: 69-76
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] The in vitro and in vivo inhibitory effect of dehydroaltenusin : a specific inhibitor of mammalian DNA polymerase α. (2006)
  • Author(s): Maeda N, Kamisuki S, Takahashi S, Yoshida H, Sakaguchi K, Sugawara F, Mizushina Y
  • Journal Title: Current Bioactive Compound. 2 Pages: 3-11
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Structural analysis of mogrol and its glycoside as inhibitors of animal DNA polymerase and human cancer cell growth. (2006)
  • Author(s): Mizushina Y, Akihisa T, Hayakawa Y, Takeuchi T, Kuriyama I, Yonezawa Y, Takemura M, Kato I, Sugawara F, Yoshida H
  • Journal Title: Letters in Drug ＆ Discovery 3 Pages: 253-260
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Synthesis and absolute configuration of (+)-pseudodeflectusin : structural revision of aspergione B. (2006)
  • Author(s): F.Saito, K.Kuramochi, A.Nakazaki, Y.Mizushina, F.Sugawara, S.Kobayashi.
  • Journal Title: Euro J. Org. Chem. 21 Pages: 4796-4799
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] An emulsion of sulfoquinovosylacylglycerol with long-chain alkanes increases its permeability to tumor cells. (2006)
  • Author(s): Aoki S, Ohta K, Matsumoto K, Sakai H, Abe M, Miura M, Sugawara F, Sakaguchi K.
  • Journal Title: J Membr Biol. 213(1) Pages: 11-8
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Synthesis of plakevulin A and structure-activity relationships of its related compounds against DNA polymerases. (2006)
  • Author(s): Kuramochi K., Saito F., Takeuchi R., Era T., Takemura M., Kobayashi J., Sakaguchi K., Kobayashi S., Sugawara.F.
  • Journal Title: Tertrahedron 62 Pages: 8006-15
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Characterization of a second proliferating cell nuclear antigen (PCNA2) from Drosophila melanogaster. (2006)
  • Author(s): Ruike T, Takeuchi R, Takata K, Oshige M, Kasai N, Shimanouchi K, Kanai Y, Nakamura R, Sugawara F, Sakaguchi K.
  • Journal Title: FEBS J. Nov;273(22) Pages: 5062-73
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Total synthesis and stereochemistry of the antitumor antibiotics PD 113,271. (2006)
  • Author(s): Takeuchi T, Kuramochi K, Kobayashi S, Sugawara F.
  • Journal Title: Org Lett. Nov 9;8(23) Pages: 5307-10
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Identification of Antibiotic Clarithromycin Binding Peptide Displayed by T7 Phage Particles. (2006)
  • Author(s): Morimura T, Noda N, Kato Y, Watanabe T, Saitoh T, Yamazaki T, Takata K, Aoki S, Ohta K, Ohshige M, Sakaguchi K, Sugawara F.
  • Journal Title: J Antibiot. 59(10) Pages: 625-632
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Site-directed mutational analysis of structural interactions of low molecule compounds binding to the N-terminal 8kDa domain of DNA polymerase beta.. (2006)
  • Author(s): Murakami S, Kamisuki S, Takata K, Kasai N, Kimura S, Mizushina Y, Ohta K, Sugawara F, Sakaguchi K
  • Journal Title: Biochem Biophys Res Commun. 350(1) Pages: 7-16
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The inhibitory action of long-chain fatty acids on the DNA binding activity of p53. (2006)
  • Author(s): Iijima H, Kasai N, Chiku H, Murakami S, Sugawara F, Sakaguchi K, Yoshida H, Mizushina Y.
  • Journal Title: Lipids. 41(6) Pages: 521-7
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Structural relationship of curcumin derivatives binding to the BRCT domain of human DNA polymerase lambda. (2006)
  • Author(s): Takeuchi T, Ishidoh T, Iijima H, Kuriyama I, Shimazaki N, Koiwai O, Kuramochi K, Kobayashi S, Sugawara F, Sakaguchi K, Yoshida H, Mizushina Y.
  • Journal Title: Genes Cells. 11(3) Pages: 223-35
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Total synthesis of (-)-neoechinulin A. (2006)
  • Author(s): Aoki T, Kamisuki S, Kimoto M, Ohnishi K, Takakusagi Y, Kuracmohi K, Takeda Y, Nakazaki A, Kuroiwa K, Ohuchi T, Sugawara F, Arai T, Kobayashi S.
  • Journal Title: Synlett. Pages: 677-680
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Alpha-sulfoquinovosylmonoacylglycerol is a novel potent radiosensitizer targeting tumor angiogenesis. (2006)
  • Author(s): Sakimoto I, Ohta K, Yamazaki T, Ohtani S, Sahara H, Sugawara F, Sakaguchi K, Miura M.
  • Journal Title: Cancer Res. 15;66(4) Pages: 2287-95
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Structural relationship of curcumin derivatives binding to the BRCT domain of human DNA polymerase lambda. (2006)
  • Author(s): Takeuchi T, Ishidoh T, Iijima H, Kuriyama I, Shimazaki N, Koiwai O, Kuramochi K, Kobayashi S, Sugawara F, Sakaguchi K, Yoshida H, Mizushina Y
  • Journal Title: Genes Cells. 11(3) Pages: 223-35
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A high-throughput phage display screening method using a combination of real-time PCR and affinity chromatography. (2006)
  • Author(s): Morohashi K, Arai T, Saito S, Watanabe M, Sakaguchi K, Sugawara F.
  • Journal Title: Comb Chem High Throughput Screen. 9(1) Pages: 55-61
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] 5-(Hydroxymethyl)-2-furfural : a selective inhibitor of DNA polymerase lambda and terminal deoxynucleotidyltransferase. (2006)
  • Author(s): Mizushina Y, Yagita E, Kuramochi K, Kuriyama I, Shimazaki N, Koiwai O, Uchiyama Y, Yomezawa Y, Sugawara F, Kobayashi S, Sakaguchi K, Yoshida H.
  • Journal Title: Arch Biochem Biophys. 446(1) Pages: 69-76
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The in vitro and in vivo inhibitory effect of dehydroaltenusin : a specific inhibitor of mammalian DNA polymerase a. (2006)
  • Author(s): Maeda N, Kamisuki S, Takahashi S, Yoshida H, Sakaguchi K, Sugawara F, Mizushina Y
  • Journal Title: Current Bioactive Compound. 2 Pages: 3-11
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Structural analysis of mogrol and its glycoside as inhibitors of animal DNA polymerase and human cancer cell growth. (2006)
  • Author(s): Mizushina Y, Akihisa T, Hayakawa Y, Takeuchi T, Kuriyama I, Yonezawa Y, Takemura M, Kato I, Sugawara F, Yoshida H.
  • Journal Title: Letters in Drug ＆ Discovery. 3 Pages: 253-60
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] In vivo target molecule screening of a bioactive natural product.. (2006)
  • Author(s): Aoki S, Ohta K, Sugawara F, Sakaguchi K
  • Journal Title: Proceedings of Sapporo Medicinal School. 6 Pages: 27-34
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] 生理活性物質Sulfoquinovosylacylglycerolの生体内標的分子検索. (2005)
  • Author(s): Aoki S, Ohta K, Sugawara F., Sakaguchi K.
  • Journal Title: 札幌医科大学医学部付属臨海医学研究所紀要 6 Pages: 27-34
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Effective form of sulfoquinovosyldiacyglycerol (SQDG) vesicles for DNA polymerase inhibition. (2005)
  • Author(s): Matsumoto K, Sakai H, Takeuchi R, Tsuchiya K, Ohta K, Sugawara F, Abe M, Sakaguchi K
  • Journal Title: Colloids Surf B Biointerfaces 46(3) Pages: 175-181
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Sulfo-quinovosyl-acyl-glycerol (SQAG), a eukaryotic DNA polymerase inhibitor and anti-cancer agent. (2005)
  • Author(s): Mizushina Y, Kasai N, Iijima H, Sugawara F, Yoshida H, Sakaguchi K
  • Journal Title: Curr Med Chem Anticancer Agents 5(6) Pages: 613-625
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Monoacetylcurcumin : a new inhibitor of eukaryotic DNA polymerase lambda and a new ligand for inhibitor-affinity chromatography. (2005)
  • Author(s): Mizushina Y, Ishidoh T, Takeuchi T, Shimazaki N, Koiwai O, Kuramochi K, Kobayashi S, Sugawara F, Sakaguchi K, Yoshida H
  • Journal Title: Biochem Biophys Res Commun. 337(4) Pages: 1288-1289
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Synthesis of a biotinylated camptothecin derivative and determination of the binding sequence by T7 phage display technology. (2005)
  • Author(s): Takakusagi Y, Ohta K, Kuramochi K, Morohashi K, Kobayashi S, Sakaguchi K, Sugawara F
  • Journal Title: Bioorg Med Chem Lett. 15(21) Pages: 4846-4849
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Sulfoquinovosylmonoacylglycerol inhibitory mode analysis of rat DNA polymerase beta. (2005)
  • Author(s): Kasai N, Mizushina Y, Murata H, Yamazaki T, Ohkubo T, Sakaguchi K, Sugawara F
  • Journal Title: FEBS J. 272(12) Pages: 4349-4361
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Camptothecin binds to a synthetic peptide identified by a T7 phage display screen. (2005)
  • Author(s): Takakusagi Y, Kobayashi S, Sugawara F
  • Journal Title: Bioorg Med Chem Lett. 15(21) Pages: 4850-4853
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Selective inhibitors of terminal deoxyribonucleotidyltransferase (TdT) : baicalin and genistin. (2005)
  • Author(s): Uchiyama Y, Tagami J, Kamisuki S, Kasai N, Oshige M, Chiku H, Ibe S, Koiwai O, Sugawara F, Sakaguchi K
  • Journal Title: Biochim Biophys Acta. 1725(3) Pages: 298-304
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Structural analysis of catechin derivatives as mammalian DNA polymerase inhibitors. (2005)
  • Author(s): Mizushina Y, Saito A, Tanaka A, Nakajima N, Kuriyama I, Takemura M, Takeuchi T, Sugawara F, Yoshida H
  • Journal Title: Biochem Biophys Res Commun. 333(1) Pages: 101-109
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Structural analysis of isosteviol and related compounds as DNA polymerase and DNA topoisomerase inhibitors. (2005)
  • Author(s): Mizushina Y, Akihisa T, Ukiya M, Hamasaki Y, Murakami-Nakai C, Kuriyama I, Takeuchi T, Sugawara F, Yoshida H
  • Journal Title: Life Sci. 77(17) Pages: 2127-2140
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] The entrapment of kojic oleate in bilayer vesicles (2005)
  • Author(s): Manosroi A, Wongtrakul P, Manosroi J, Midorikawa U, Hanyu Y, Yuasa M, Sugawara F, Sakai H, Ahe M
  • Journal Title: Int J Pharm. 298(1) Pages: 13-25
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Identification of a drug target motif : an anti-tumor drug NK109 interacts with a PNxxxxP. (2005)
  • Author(s): Morohashi K, Yoshino A, Yoshimori A, Saito S, Tanuma S, Sakaguchi K, Sugawara F
  • Journal Title: Biochem Pharmacol. 70(1) Pages: 37-46
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Mammalian mitotic centromere-associated kinesin (MCAK) : a new molecular target of sulfoquinovosylacylglycerols novel antitumor and immunosuppressive agents. (2005)
  • Author(s): Aoki S, Ohta K, Yamazaki T, Sugawara F, Sakaguchi K
  • Journal Title: FEBS J. 272(9) Pages: 2132-2140
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Mechanism of the immunosuppressive effect in vivo of novel immunosuppressive drug beta-SQAG9, which inhibits the response of the CD62L+ T-cell subset. (2005)
  • Author(s): Takenouchi M, Sahara H, Yamamoto Y, Matsumoto Y, Imai A, Fujita T, Tamura Y, Takahashi N, Gasa S, Matsumoto K, Ohta K, Sugawara F, Sakaguchi K, Jimbow K, Sato N
  • Journal Title: Transplant Proc. 37(1) Pages: 139-142
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Structural analysis of epolactaene derivatives as DNA polymerase inhibitors and anti-inflammatory compounds. (2005)
  • Author(s): Mizushina Y, Kuramochi K, Ikawa H, Kuriyama I, Shimazaki N, Takemura M, Oshige M, Yoshida H, Koiwai O, Sugawara F, Kobayashi S, Sakaguchi K
  • Journal Title: Int J Mol Med. 15(5) Pages: 785-793
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Affinity capture of a mammalian DNA polymerase beta by inhibitors immobilized to resins used in solid-phase organic synthesis. (2005)
  • Author(s): Kuramochi K, Haruyama T, Takeuchi R, Sunoki T, Watanabe M, Oshige M, Kobayashi S, Sakaguchi K, Sugawara F
  • Journal Title: Bioconjug Chem. 16(1) Pages: 97-104
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Monolayer membranes and bilayer vesicles characterized by alpha-and beta-anomer of sulfoquinovosyldiacyglycerol (SODG). (2005)
  • Author(s): Matsumoto K, Sakai H, Ohta K, Kameda H, Sugawara F, Abe M, Sakaguchi K
  • Journal Title: Chem Phys Lipids. 133(2) Pages: 203-214
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Three-dimensional structural analysis of the binding site of two inhibitors, nervonic acid and lithocholic acid, of DNA polymerase βand DNA topoisomerase II. (2005)
  • Author(s): Mizushina Y, Kasai N, Sugawara F, Yoshida H, Sakaguchi K
  • Journal Title: Current Computer-Aided Drug Design 1 Pages: 9-91
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Effective form of sulfoquinovosyldiacyglycerol (SQDG) vesicles for DNA polymerase inhibition. (2005)
  • Author(s): Matsumoto K, Sakai H, Takeuchi R, Tsuchiya K, Ohta K, Sugawara F, Abe M, Sakaguchi K.
  • Journal Title: Colloids Surf B Biointerfaces. 46(3) Pages: 175-81
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Sulfo-quinovosyl-acyl-glycerol (SQAG), a eukaryotic DNA polymerase inhibitor and anti-cancer agent.. (2005)
  • Author(s): Mizushina Y, Kasai N, Iijima H, Sugawara F, Yoshida H, Sakaguchi K
  • Journal Title: Curr Med Chem Anticancer Agents. 5(6) Pages: 613-25
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Monoacetylcurcumin : a new inhibitor of eukaryotic DNA polymerase lambda and a new ligand for inhibitor-affinity chromatography.. (2005)
  • Author(s): Mizushina Y, Ishidoh T, Takeuchi T, Shimazaki N, Koiwai O, Kuramochi K, Kobayashi S, Sugawara F, Sakaguchi K, Yoshida H
  • Journal Title: Biochem Biophys Res Commun. 337(4) Pages: 1288-95
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Selective inhibitors of terminal deoxyribonucleotidyltransferase (TdT) : baicalin and genistin. (2005)
  • Author(s): Uchiyama Y, Tagami J, Kamisuki S, Kasai N, Oshige M, Chiku H, Ibe S, Koiwai O, Sugawara F, Sakaguchi K.
  • Journal Title: Biochim. Biophys. Acta 1725(3) Pages: 298-304
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The entrapment of kojic oleate in bilayer vesicles. Manosroi A (2005)
  • Author(s): Wongtrakul P, Manosroi J, Midorikawa U, Hanyu Y, Yuasa M, Sugawara F, Sakai H, Abe M.
  • Journal Title: Int J Pharm. 298(1) Pages: 13-25
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Synthesis of a biotinylated camptothecin derivative and determination of the binding sequence by T7 phage display technology. (2005)
  • Author(s): Takakusagi Y, Ohta K, Kuramochi K, Morohashi K, Kobayashi S, Sakaguchi K, Sugawara F.
  • Journal Title: Bioorg. Med. Chem. Lett. 15 Pages: 4846-49
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Camptothecin binds to a synthetic peptide identified by a T7 phage display screen. (2005)
  • Author(s): Takakusagi Y, Kobayashi S, Sugawara F.
  • Journal Title: Bioorg. Med. Chem. Lett. 15 Pages: 4850-53
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Sulfoquinovosylmonoacylglycerol inhibitory mode analysis of rat DNA polymerase β. (2005)
  • Author(s): Kasai N, Mizushina Y, Murata H, Yamazaki T, Ohkubo T, Sakaguchi K, Sugawara F.
  • Journal Title: FEBS J. 272 Pages: 4349-61
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Structural analysis of isosteviol and related compounds as DNA polymerase and DNA topoisomerase inhibitors. (2005)
  • Author(s): Mizushina Y, Akihisa T, Ukiya M, Hamasaki Y, Murakami-Nakai C, Kuriyama I, Takeuchi T, Sugawara F, Yoshida H.
  • Journal Title: Life Sci. 77 Pages: 2127-40
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Structural analysis of catechin derivatives as mammalian DNA polymerase inhibitors. (2005)
  • Author(s): Mizushina Y, Saito A, Tanaka A, Nakajima N, Kuriyama I, Takemura M, Takeuchi T, Sugawara F, Yoshida H.
  • Journal Title: Biochem. Biophys. Res. Commun. 333 Pages: 101-9
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Structural analysis of epolactaene derivatives as DNA polymerase inhibitors and anti-inflammatory compounds. (2005)
  • Author(s): Mizushina Y, Kuramochi K, Ikawa H, Kuriyama I, Shimazaki N, Takemura M, Oshige M, Yoshida H, Koiwai O, Sugawara F, Kobayashi S, Sakaguchi K.
  • Journal Title: Int. J. Mol. Med. 15 Pages: 785-93
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Identification of a drug target motif : An anti-tumor drug NK109 interacts with a PNxxxxP. (2005)
  • Author(s): Morohashi K, Yoshino A, Yoshimori A, Saito S, Tanuma S, Sakaguchi K, Sugawara F.
  • Journal Title: Biochem. Pharmacol. 70 Pages: 37-46
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Mammalian mitotic centromere-associated kinesin (MCAK), a new molecular target of sulfoquinovosylacylglycerols (SQAGs), novel anti-tumor and immunosuppressive agents. (2005)
  • Author(s): Aoki S, Kamisuki S, Ohta S, Sugawara F, Sakaguchi K.
  • Journal Title: FEBS J. 272 Pages: 2132-40
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Monolayer membranes and bilayer vesicles characterized by α- and β-anomer of sulfoquinovosyldiacylglycerol (SQDG). (2005)
  • Author(s): Matsumoto K, Sakai H, Ohta K, Kameda H, Sugawara F, Abe M, Sakaguchi K.
  • Journal Title: Chem. Phys. Lipids. 133 Pages: 203-14
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Affinity capture of a mammalian DNA polymerase p by inhibitors immobilized to resins used in solid-phase organic synthesis. (2005)
  • Author(s): Kuramochi K, Haruyama Y, Takeuchi R, Sunoki T, Watanabe M, Oshige M, Kobayashi S, Sakaguchi K, Sugawara F.
  • Journal Title: Bioconjugate Chem. 16 Pages: 203-14
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Mechanism of the immunosuppressive effect in vivo of novel immunosuppressive drug beta-SQAG9, which inhibits the response of the CD62L+ T-cell subset. (2005)
  • Author(s): Takenouchi M, Sahara H, Yamamoto Y, Matsumoto Y, Imai A, Fujita T, Tamura Y, Takahashi N, Gasa S, Matsumoto K, Ohta K, Sugawara F, Sakaguchi K, Jimbow K, Sato N.
  • Journal Title: Transplant. Proc. 37 Pages: 139-42
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Three-dimensional structural analysis of the binding site of two inhibitors, nervonic acid and lithocholic acid, of DNA polymerase β and DNA topoisomerase II. (2005)
  • Author(s): Mizushina Y, Kasai N, Sugawara F, Yoshida H, Sakaguchi K.
  • Journal Title: Current Computer-Aided Drug Design 1 Pages: 9-91
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Inhibition of CD62L+ T-cell response in vitro via a novel sulfo-glycolipid, beta-SQAG9 liposome that binds to CD62L molecule on the cell surface. (2004)
  • Author(s): Yamamoto Y, Sahara H, Takenouchi M, Matsumoto Y, Imai A, Fujita T, Tamura Y, Takahashi N, Gasa S, Matsumoto K, Ohta K, Sugawara F, Sakaguchi K, Jimbow K, Sato N
  • Journal Title: Cell Immuno 232(1-2) Pages: 105-115
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Design of vesicles of 1,2-di-O-acyl-3-O-(beta-D-sulfoquinovosyl)-glyceride bearing two stearic acids (beta-SQDG-C(18)), a novel immunosuppressive drug. (2004)
  • Author(s): Matsumoto K, Takenouchi M, Ohta K, Ohta Y, Imura T, Oshige M, Yamamoto Y, Sahara H, Sakai H, Abe M, Sugawara F, Sato N, Sakaguchi K
  • Journal Title: Biochem Pharmacol. 68 Pages: 2379-2386
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Synthesis of an immunosuppressant SQAG9 and determination of the binding peptide by T7 phase display. (2004)
  • Author(s): Yamazaki T, Aoki S, Ohta K, Hyuma S, Sakaguchi K, Sugawara F
  • Journal Title: Bioorg Med Chem Lett. 14 Pages: 4343-4346
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Structural relationship of lithocholic acid derivatives binding to the N-terminal 8-kDa domain of DNA polymerase beta. (2004)
  • Author(s): Miura K, Hanashima S, Takemura M, Yoshida H, Sugawara F, Sakaguchi K
  • Journal Title: Biochemistry 43 Pages: 10669-10677
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Precise structural elucidation of dehydroaltenusin, a specific inhibitor of mammalian DNA polymerase alpha (2004)
  • Author(s): Kamisuki S, Takahashi S, Mizushina Y, Sakaguchi K, Nakata T, Sugawara F
  • Journal Title: Bioorg Med Chem 12 Pages: 5355-5359
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Molecular design of cholesterols as inhibitors of DNA polymerase alpha. (2004)
  • Author(s): Oshige M, Kuramochi K, Ohta K, Ogawa A, Kuriyama H, Sugawara F, Kobayashi S, Sakaguchi K
  • Journal Title: J Med Chem. 47 Pages: 4971-4974
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Structure-activity relationships of epolactaene analogs as DNA polymerases inhibitors. (2004)
  • Author(s): Kuramochi K, Mizushina Y, Nagata S, Sugawara F, Sakaguchi K, Kobayashi S
  • Journal Title: Bioorg Med Chem. 12 Pages: 1983-1989
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Structure-activity relationships of untenone A and its derivatives for inhibition of DNA polymerases (2004)
  • Author(s): Saito F, Takeuchi R, Kamino T, Kuramochi K, Sugawara F, Sakaguchi K, Kobayashi S
  • Journal Title: Bioorg Med Chem Lett. 14 Pages: 1975-1977
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Protective properties of neoechinulin A against SIN-1-induced neuronal cell death. (2004)
  • Author(s): Maruyama K, Ohuchi T, Yoshida K, Shibata Y, Sugawara F, Arai T
  • Journal Title: J Biochem. (Tokyo) 36 Pages: 81-87
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Synthetic sulfonolipids deduced from sulfonoquinovosyl diacylglycerols of sea urchin reduces hepatic ischemia-reperfusion injury in rats. (2004)
  • Author(s): Tsuruma T, Sahara H, Takenouchi M, Yagihashi A, Iwayama Y, Shima H, Furuhata T, Torigoe T, Hanashima S, Yamazaki T, Sugawara F, Mizushina Y, Ohta K, Sakaguchi K, Sato N, Hirata K
  • Journal Title: Transplant Proc 36 Pages: 1965-1969
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] The effects of dehydroaltenusin, a novel mammalian DNA polymerase alpha inhibitor, on cell proliferation and cell cycle progression. (2004)
  • Author(s): Murakami-Nakai C, Maeda N, Yonezawa Y, Kuriyama I, Kamisuki S, Takahashi S, Sugawara F, Yoshida H, Sakaguchi K, Mizushina Y
  • Journal Title: Biochim. Biophys. Acta. 1674 Pages: 193-199
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Pseudodeflectusin, a novel isochroman derivative from Aspergillus pseudodeflectus a parasite of the sea weed, Sargassum fusiform, as a selective human cancer cytotoxin (2004)
  • Author(s): Ogawa A, Murakami C, Kamisuki S, Kuriyama I, Yoshida H, Sugawara F, Mizushina Y
  • Journal Title: Bioorg Med Chem Lett. 14 Pages: 3539-3543
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Taxol derivatives are selective inhibitors of DNA polymerase alpha. (2004)
  • Author(s): Oshige M, Takenouchi M, Kato Y, Kamisuki S, Takeuchi T, Kuramochi K, Shiina I, Suenaga Y, Kawakita Y, Kuroda K, Sato N, Kobayashi S, Sugawara F, Sakaguchi K
  • Journal Title: Bioorg Med Chem. 12 Pages: 2597-2601
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Total synthesis of dehydroaltenusin (2004)
  • Author(s): Kamisuki S, Takahashi S, Mizushina Y, Hanashima S, Kuramochi K, Kobayashi S, Sakaguchi K, Nakata T, Sugawara F
  • Journal Title: Tetrahedron 60 Pages: 5695-5698
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] A tublin-based quantitative assay for Taxol (Paclitaxel) with enzyme channeling sensing. (2004)
  • Author(s): Suye S, Nakamoto D, Hori T, Sugawara F, Mulchandani A
  • Journal Title: Electroanalysis 16 Pages: 688-690
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Synthesis of the proposed structure of plakevulin A : revised structure of plakevulin A. (2004)
  • Author(s): Saito F, Takeuchi R, Kamino T, Kuramochi K, Sugawara F, Sakaguchi K, Kobayashi S, Tsuda M, Kobayashi J
  • Journal Title: Tetrahedron Lett. 45 Pages: 8069-8071
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Total synthesis of dehydroaltenusin. (2004)
  • Author(s): Kamisuki S, Takahashi S, Mizushina Y, Hanashima S, Kuramochi K, Kobayashi S, Sakaguchi K, Nakata T, Sugawara F.
  • Journal Title: Tetrahedron 60 Pages: 5695
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Inhibition of CD62L(+) T-cell response in vitro via a novel sulfo-glycolipid, beta-SQAG9 liposome that binds to CD62L molecule on the cell surface. (2004)
  • Author(s): Yamamoto Y, Sahara H, Takenouchi M, Matsumoto Y, Imai A, Fujita T, Tamura Y, Takahashi N, Gasa S, Matsumoto K, Ohta K, Sugawara F, Sakaguchi K, Jimbow K, Sato N.
  • Journal Title: Cell Immunol. 232 Pages: 105-115
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Synthetic sulfonolipids deduced from sulfonoquinovosyldiacylglycerols of sea urchin reduces hepatic ischemia-reperfusion injury in rats. (2004)
  • Author(s): Tsuruma T, Sahara H, Takenouchi M, Yagihashi A, Iwayama Y, Shima H, Furuhata T, Torigoe T, Hanashima S, Yamazaki T, Sugawara F, Mizushina Y, Ohta K, Sakaguchi K, Sato N, Hirata K.
  • Journal Title: Transplant. Proc. 36 Pages: 1965-1969
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Design of vesicles of 1,2-di-O-acyl-3-O-(beta-D-sulfoquinovosyl)-glyceride bearing two stearic acids (beta-SQDG-C(18)), a novel immunosuppressive drug. (2004)
  • Author(s): Matsumoto K, Takenouchi M, Ohta K, Ohta Y, Imura T, Oshige M, Yamamoto Y, Sahara H, Sakai H, Abe M, Sugawara F, Sato N, Sakaguchi K.
  • Journal Title: Biochem. Pharmacol. 68 Pages: 2379-2386
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Synthesis of an immunosuppressant SQAG9 and determination of the binding peptide by T7 phage display. (2004)
  • Author(s): Yamazaki T, Aoki S, Ohta K, Haruyama S, Sakaguchi K, Sugawara F.
  • Journal Title: Bioorg. Med. Chem. Lett. 14 Pages: 4343-4346
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Structural relationship of lithocholic acid derivatives binding to the N-terminal 8-kDa domain of DNA polymerase beta. (2004)
  • Author(s): Miura K, Hanashima S, Takemura M, Yoshida H, Sugawara F, Sakaguchi K.
  • Journal Title: Biochem. 43 Pages: 10669-10677
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Precise structural elucidation of dehydroaltenusin, a specific inhibitor of mammalian DNA polymerase alpha. (2004)
  • Author(s): Kamisuki S, Takahashi S, Mizushina Y, Sakaguchi K, Nakata T, Sugawara F.
  • Journal Title: Bioorg. Med. Chem. 12 Pages: 5355-5359
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Molecular design of cholesterols as inhibitors of DNA polymerase alpha. (2004)
  • Author(s): Ohshige M, Kuramochi K, Ohta K, Ogawa A, Kuriyama H, Sugawara F, Kobayashi S, Sakaguchi K.
  • Journal Title: J. Med. Chem. 47 Pages: 4971-4974
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Structure-activity relationships of epolactaene analogs as DNA polymerases inhibitors. (2004)
  • Author(s): Kuramochi K, Mizushina Y, Nagata S, Sugawara F, Sakaguchi K, Kobayashi S.
  • Journal Title: Bioorg. Med. Chem. 12 Pages: 1983-1989
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Structure-activity relationships of untenone A and its derivatives for inhibition of DNA polymerases. (2004)
  • Author(s): Saito F, Takeuchi R, Kamino T, Kuramochi K, Sugawara F, Sakaguchi K, Kobayashi S.
  • Journal Title: Bioorg. Med. Chem. Lett. 14 Pages: 1975-1977
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Protective properties of neoechinulin A against SIN-1-induced neuronal cell death. (2004)
  • Author(s): Maruyama K, Ohuchi T, Yoshida K, Shibata Y, Sugawara F, Arai T.
  • Journal Title: J. Biochem. (Tokyo). 36 Pages: 81-87
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The effects of dehydroaltenusin, a novel mammalian DNA polymerase alpha inhibitor, on cell proliferation and cell cycle progression. (2004)
  • Author(s): Murakami-Nakai C, Maeda N, Yonezawa Y, Kuriyama I, Kamisuki S, Takahashi S, Sugawara F, Yoshida H, Sakaguchi K, Mizushina Y.
  • Journal Title: Biochim. Biophys. Acta. 1674 Pages: 193-199
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Pseudodeflectusin, a novel isochroman derivative from Aspergillus pseudodeflectus a parasite of the sea weed, Sargassum fusiform, as a selective human cancer cytotoxin. (2004)
  • Author(s): Ogawa A, Murakami C, Kamisuki S, Kuriyama I, Yoshida H, Sugawara F, Mizushina Y.
  • Journal Title: Bioorg. Med. Chem. Lett. 14 Pages: 3539-3543
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Taxol derivatives are selective inhibitors of DNA polymerase alpha. (2004)
  • Author(s): Oshige M, Takenouchi M, Kato Y, Kamisuki S, Takeuchi T, Kuramochi K, Shiina I, Suenaga Y, Kawakita Y, Kuroda K, Sato N, Kobayashi S, Sugawara F, Sakaguchi K.
  • Journal Title: Bioorg. Med. Chem. 12 Pages: 2597-2601
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Synthesis of the proposed structure of plakevulin A : revised structure of plakevulin A. (2004)
  • Author(s): Saito F, Takeuchi R, Kamino T, Kuramochi K, Sugawara F, Sakaguchi K, Kobayashi S, Tsuda M, Kobayashi J.
  • Journal Title: Tetrahedron Lett. 45 Pages: 8069-8071
  • Description: 「研究成果報告書概要(欧文)」より
• [Book] 生物有機化学 基礎化学編 (2007)
  • Author(s): 菅原 二三男 監訳
  • Total Pages: 400
  • Publisher: 丸善
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 生物有機化学 有機化学編 (2007)
  • Author(s): 菅原 二三男 監訳
  • Total Pages: 200
  • Publisher: 丸善
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 生物有機化学 生化学編 (2007)
  • Author(s): 菅原 二三男 監訳
  • Total Pages: 400
  • Publisher: 丸善
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] RADIOSENSITIZER (2007)
  • Inventor(s): 菅原二三男, 山崎隆
  • Industrial Property Rights Holder: 東洋水産(株)
  • Industrial Property Number: European Patent 05765113.5-1211-JP2005011630
  • Acquisition Date: 2007-01-07
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] 新規イソクロマノン化合物とその行為丸剤への利用 (2004)
  • Inventor(s): 菅原二三男, 水品善
  • Industrial Property Rights Holder: 東京理科大学
  • Industrial Property Number: 国内特許出願2004-123491
  • Filing Date: 2004-04-19
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] 新規な放射線治療増感剤. (2004)
  • Inventor(s): 菅原二三男, 山崎隆
  • Industrial Property Rights Holder: 東京理科大学
  • Industrial Property Number: 国内特許出願2004-186480
  • Filing Date: 2004-06-24
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] Administration of a sulfopyranosylacylglycerol to treat certain cancer (2004)
  • Inventor(s): 菅原二三男, 山崎隆
  • Industrial Property Rights Holder: 東洋水産(株)
  • Industrial Property Number: US Patent US6770629 B2
  • Acquisition Date: 2004-08-03
  • Description: 「研究成果報告書概要(和文)」より