2006 Fiscal Year Final Research Report Summary
Studies on the relationships between cellular immunological parameters and polymorphisms of immune-related genes and their implications in disease development among the A-bomb survivor cohort
| Project/Area Number |
16390190
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | Radiation Effects Research Foundation |
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Principal Investigator |
KUSUNOKI Yoichiro Radiation Effects Research Foundation, Department of Radiobiology/Molecular Epidemiology, Assistant Chief, 放射線生物学/分子疫学部, 副部長 (60333548)
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| Co-Investigator(Kenkyū-buntansha) |
HAYASHI Tomonori Radiation Effects Research Foundation, Department of Radiobiology/Molecular Epidemiology, Chief of Immunology Laboratory, 放射線生物学/分子疫学部, 免疫学研究室長 (70333549)
KYOIZUMI Seishi Yasuda Women's University, Department of Nutritional Sciences, Professor, 家政学部, 教授 (50333547)
HAKLODA Masayuki Yasuda Women's University, Department of Nutritional Sciences, Professor, 家政学部, 教授 (70208429)
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| Project Period (FY) |
2004 – 2006
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| Keywords | Cohort study / Cellular immunity / Molecular epidemiology / Radiation / Cytokine / Virus hepatitis / Th1 / Th2 |
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| Research Abstract |
To address whether immunogenetic background may determine individual susceptibility to disease among A-bomb survivors, we examined the relationships between cellular immunological parameters and polymorphisms of immune-related genes and analyzed their associations with disease development. The following results were obtained in this study period.
1.A radiation dose-dependent decrease in percentage of naive CD4 T cells in both Hiroshima and Nagasaki survivors; this is possibly due to radiation-induced suppression of CD4 T-cell production in the thymus.
2.Dose-dependent increases in percentages of the functionally weak and anergic subsets of memory CD4 T cells that were identified by CD43 expression level.
3.Dose-dependent increases in the levels of inflammatory cytokines (IL-6, IFN-γ, and TNF-α) in the blood.
4.Th1-dominant status associated with elevation of inflammatory cytokine levels in individuals with HCV infection as well as in progression of chronic hepatitis.
5.No significant phenotype-genotype association in inflammatory cytokine (IL-6, IFN-γ, and TNF-α) genes ; genotypes of these genes are unlikely to interact with radiation effects.
6.A suggestive association between CD45 exon 6 SNP (A138G) and proportion of Th1/Th2 cells.
A follow-up study regarding disease development will be continued for the subjects in this study. Thus, this study provided not only evidence supporting our hypothesis that A-bomb irradiation has accelerated immunological aging but also a strong basis for further cohort study investigating relationships among radiation exposure, biological endpoints of cellular immunity, genetic backgrounds, and disease risks in a large human population.
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Research Products
(35 results)
