Study on the mechanism of development of differentiated adenocarcinoma from intestinal metaplasia

2005 Fiscal Year Final Research Report Summary

• Project/Area Number: 16390214
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: JICHI MEDICAL SCHOOL
• Principal Investigator: SUGANO Kentaro JICHI MEDICAL SCHOOL, School of Medicine, Professor, 医学部, 教授 (60179116)
• Co-Investigator(Kenkyū-buntansha): SATOH Kiichi JICHI MEDICAL SCHOOL, School of Medicine, Senior Lecturer, 医学部, 講師 (50275707) ; MUTOH Hiroyuki JICHI MEDICAL SCHOOL, School of Medicine, Senior Lecturer, 医学部, 講師 (50322392) ; OSAWA Hiroyuki JICHI MEDICAL SCHOOL, School of Medicine, Assistant Lecturer, 医学部, 助手 (70260833)
• Project Period (FY): 2004 – 2005
• Keywords: Intestinal Metaplasia / Gastric Cancer / Transgenic mouse / Transcriptional Factor / Cdx1, 2 / Math 1 / Sonic Hedgehog

Research Abstract

Intestinal metaplasia has been considered as a condition predisposing cancer development.
However, no direct evidence on cancer development from intestinal metaplasia has been provided.
In this research project, we could demonstrate that gastric adenocarcinoma with differentiated histological features developed from intestinal metaplasia in the cdx-2 expressing transgenic mice stomach. The analysis of genetic alteration revealed that mutational events frequently observed in human gastric cancer (such as p53 or APC gene mutations or truncations) occurred in the mice tumors. Therefore, this model will be quite useful for analyzing the molecular events leading to carcinogenesis and also for interventional studies to suppress cancer development.

Research Products

• [Journal Article] The intestine-specific homeobox gene Cdx2 induces expression of the basic helix-loop-helix transcription factor Mathl (2006)
  • Author(s): Hiroyuki Mutoh, Hirotsugu Sakamoto, Hiroko Hayakawa, Yukitomo Aroa, Kiichi Satoh, Mitsuhiro Nokubi, Kentaro Sugano
  • Journal Title: Differentiation (in press)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Pericryptal fibroblast sheath in intestinal metaplasia and gastric carcinoma (2005)
  • Author(s): Mutoh H, Sakurai S, Satoh K, Osawa H, Tomiyama T, Kita H, Yoshida T, Tamada K, Yamamoto H, Isoda N, Ido K, Sugano K
  • Journal Title: Gut 54 Pages: 33-39
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Cdx2 specifies the differentiation of morphological as well as functional absorptive enterocytes of the small intestine (2005)
  • Author(s): Mutoh H, Satoh K, Kita H, Sakamoto H, Hayakawa H, Yamamoto H, Isoda N, Tamada K, Ido K, Sugano K
  • Journal Title: Int J Dev Biol 49 Pages: 867-871
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Pericryptal fibroblast sheath in intestinal metaplasia and gastric carcinoma. (2005)
  • Author(s): Mutoh H, Sakurai S, Satoh K, Osawa H, Tomiyama T, Kita H, Yoshida T, Tamada K, Yamamoto H, Isoda N, Ido K, Sugano K.
  • Journal Title: Gut. 54 Pages: 33-39
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Cdx2 specifies the differentiation of morphological as well as functional absorptive enterocytes of the small intestine. (2005)
  • Author(s): Mutoh H, Satoh K, Kita H, Sakamoto H, Hayakawa H, Yamamoto H, Isoda N, Tamada K, Ido K, Sugano K
  • Journal Title: Int J Dev Biol. 49 Pages: 867-871
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Development of gastric carcinoma from intestinal metaplasia in Cdx2-transgenic mice (2004)
  • Author(s): Mutoh H, Sakurai S, Satoh K, Tamada K, Kita H, Osawa H, Tomiyama T, Sato Y, Yamamoto H, Isoda N, Yoshida T, Ido K, Sugano K
  • Journal Title: Cancer Res. 64 Pages: 7740-7747
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Cdx1 induced intestinal metaplasia in the transgenic mouse stomach : comparative study with Cdx2 transgenic mice (2004)
  • Author(s): Mutoh H, Sakurai S, Satoh K, Osawa H, Hakamata Y, Takeuchi T, Sugano K
  • Journal Title: Gut 53 Pages: 1416-1423
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Development of gastric carcinoma from intestinal metaplasia in Cdx2-transgenic mice. (2004)
  • Author(s): Mutoh H, Sakurai S, Satoh K, Tamada K, Kita H, Osawa H, Tomiyama T, Sato Y, Yamamoto H, Isoda N, Yoshida T, Ido K, Sugano K.
  • Journal Title: Cancer Res. 64 Pages: 7740-7747
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Cdx1 induced intestinal metaplasia in the transgenic mouse stomach : comparative study with Cdx2 transgenic mice. (2004)
  • Author(s): Mutoh H, Sakurai S, Satoh K, Osawa H, Hakamata Y, Takeuchi T, Sugano K.
  • Journal Title: Gut. 53 Pages: 1416-1423
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The intestine-specific homeobox gene Cdx2 induces expression of the basic helix-loop-helix transcription factor Math1
  • Author(s): Hiroyuki Mutoh, Hirotsugu Sakamoto, Hiroko Hayakawa, Yukitomo Arao, Kiichi Satoh, Mitsuhiro Nokubi, Kentaro Sugano
  • Journal Title: Differentiation (in press)
  • Description: 「研究成果報告書概要(欧文)」より